{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:13:02Z","timestamp":1764936782245},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T00:00:00Z","timestamp":1435795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale, aims and objectives<\/jats:title><jats:p>Although the condition of low haemoglobin (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b) levels has been established as a risk factor in the development of coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>), it is still a debate particularly in patients with angiographically documented disease. In the present study, we sought to identify the relationship between <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b levels and the presence of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study consisted of 356 consecutive patients referred for elective coronary angiography (<jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content>). Exclusion criteria included a history of prior <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> within last 3 months, presence of neoplastic disorders or any inflammatory diseases or overt diabetes mellitus. Blood samples for haematologic and biochemical measurements were collected on admission following at least 12 hours of overnight fasting. Patients were divided into four groups based on the quartiles of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b (quartile <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2009&lt;\u200913.50\u2009g\/dL, quartile <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> 13.50\u201314.70\u2009g\/dL, quartile <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> 14.71\u201315.74\u2009g\/dL, quartile <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2009&gt;\u200915.74\u2009g\/dL). Additionally, patients filled out a questionnaire of asking their brief medical histories and baseline characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower <jats:styled-content style=\"fixed-case\">Hb<\/jats:styled-content> quartiles were independently related to the presence of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> in subjects who were referred to elective <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content>. The patients with older age [<jats:italic>P<\/jats:italic>\u2009=\u20090.008, odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u2009=\u20091.042], male gender (<jats:italic>P<\/jats:italic>\u2009=\u20090.007, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20093.408), in quartile <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.003, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20095.697), in quartile <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20098.767), in quartile <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.011, <jats:italic>P<\/jats:italic>\u2009=\u20093.076), higher white blood cells count (<jats:italic>P<\/jats:italic>\u2009=\u20090.037, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.208), lower platelet count (<jats:italic>P<\/jats:italic>\u2009=\u20090.049, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20090.995), condition of current smoker (<jats:italic>P<\/jats:italic>\u2009=\u20090.030, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20092.548), higher value of fasting glucose (<jats:italic>P<\/jats:italic>\u2009=\u20090.014, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.038), estimated glomerular filtration rate\u2009&lt;\u200960 (mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009=\u20090.004, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20093.269) were more likely associated with the risk of the presence of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study revealed that lower quartiles of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b levels were independently related to the presence of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> in subjects who were referred to elective <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b levels, which can be measured easily in almost all medical centres, may be considered as a potential predictor for the presence of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> in patients at high risk for <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jep.12409","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T17:50:11Z","timestamp":1435945811000},"page":"937-942","source":"Crossref","is-referenced-by-count":4,"title":["Haemoglobin levels correlates with the presence of coronary artery disease"],"prefix":"10.1111","volume":"21","author":[{"given":"Yusuf C.","family":"Doganer","sequence":"first","affiliation":[{"name":"Department of Family Medicine Primary Care Examination Center Turkish Military Academy  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umit","family":"Aydogan","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Gulhane Military Medical Academy  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew E.","family":"Bernard","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Barcin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Gulhane Military Medical Academy  Ankara 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