{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T03:55:03Z","timestamp":1763178903823},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Scientific Council","award":["102-2410-H-227-010"],"award-info":[{"award-number":["102-2410-H-227-010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Abstract<\/jats:title>Rationale, aims and objectives<\/jats:title>Inappropriate antibiotic prescriptions during pregnancy may adversely affect the fetus. There were few studies on factors associated with antibiotic prescriptions potentially harmful to the fetus.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a population\u2010based cross\u2010sectional study using data from N<\/jats:styled-content>ational H<\/jats:styled-content>ealth I<\/jats:styled-content>nsurance R<\/jats:styled-content>esearch D<\/jats:styled-content>atabase. We calculated the frequency of antibiotic prescription according to the status of pregnancy, type of infections, characteristics of patients, doctors and medical institutions. According to the B<\/jats:styled-content>ritish N<\/jats:styled-content>ational F<\/jats:styled-content>ormulary, sulfonamides, trimethoprim, tetracycline and quinolones were classified as antibiotics potentially harmful to the fetus. A multivariate logistic regression analysis was performed to evaluate the independent effect of various characteristic on antibiotic prescriptions, during pregnancy, potentially harmful to the fetus.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the 19\u2009464 pregnant subjects, 6554 (33.67%) received antibiotic prescriptions during pregnancy. Antibiotic prescriptions potentially harmful to the fetus accounted for 6.31% of all antibiotic prescriptions during pregnancy. Pregnant women aged <20 years, in their first trimester, and who were presenting with urogenital infections had the highest risks of receiving antibiotic prescriptions potentially harmful to the fetus. Non\u2010gynaecologists, doctors aged 39\u201349 or \u226550 years, and doctors at clinics had higher risks of prescribing antibiotics potentially harmful to the fetus.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Measures to improve the quality of practices should include efforts to increase awareness of antibiotic prescription guidelines for the treatment of infections in the pregnant population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jep.12454","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T10:54:40Z","timestamp":1444301680000},"page":"200-206","source":"Crossref","is-referenced-by-count":8,"title":["Factors associated with potentially harmful antibiotic prescription during pregnancy: a population\u2010based study"],"prefix":"10.1111","volume":"22","author":[{"given":"Yichen","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Health Administration Tzu\u2010Chi University of Science and Technology Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuchieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Health Care Management National Taipei University of Nursing and Health Sciences Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dachen","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Health Care Management National Taipei University of Nursing and Health Sciences Taipei Taiwan"},{"name":"Department of Emergency Medicine and Surgery Taipei City Hospital Taipei Taiwan"},{"name":"Institute of Public Health and Community Medicine Research Center National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingchung","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Health Care Management National Taipei University of Nursing and Health Sciences Taipei Taiwan"},{"name":"Department of Emergency 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