{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T07:33:14Z","timestamp":1785655994277,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T00:00:00Z","timestamp":1490745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["175023"],"award-info":[{"award-number":["175023"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims and Objectives<\/jats:title><jats:p>Targeting older patients with predictive factors for drug\u2010related problems (DRPs) could make clinical medication reviews more cost\u2010effective. The aim of this study was to identify the number, type, and potential predictive factors for DRPs in older polypharmacy patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Community pharmacists performed clinical medication reviews and documented DRPs, types of interventions, and their implementation in older patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred eighty\u2010eight medication reviews were analyzed, 964 DRPs (average 2.5\u00a0\u00b1\u00a01.9), and 1022 interventions (average 2.6\u00a0\u00b1\u00a02.0) were identified. The overall implementation rate of interventions was 70.1%, the highest was observed in interventions aiming to resolve the lack of therapy monitoring (86.8%). Patients with \u226512 medications had an increased risk of \u22655 DRPs (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Asthma was associated with lack of adherence (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002), lack of aspirin, statins, and proton pump inhibitors use with additional therapy needed (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002\u2010.004). Predictive factors for drug interactions were antihypertensive medications and\/or medications with narrow therapeutic index (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Lack of efficacy was associated with diabetes (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006). Nonsteroidal anti\u2010inflammatory drugs were risk factors for inappropriate drug selection (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). Lack of monitoring was associated with hypertension (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.013), whereas benzodiazepines (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and aspirin (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.021) were overused.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with asthma, hypertension, and diabetes and lack of statin, antithrombotic agent, and\/or proton pump inhibitor use were associated with higher risks for DRPs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jep.12737","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T10:00:21Z","timestamp":1490781621000},"page":"860-865","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of drug\u2010related problems in older polypharmacy primary care patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5791-2145","authenticated-orcid":false,"given":"Sandra 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