{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:22:19Z","timestamp":1770322939088,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Health Policy Research Programme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rational, aims, and objectives<\/jats:title><jats:p>The Family Nurse Partnership (FNP) is a licensed intensive home visiting intervention developed in the United States. It has been provided in England by the Department of Health since 2006. The Building Blocks trial assessed the effectiveness and cost\u2010effectiveness of FNP in England.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cost\u2010utility analysis (National Health Service (NHS) perspective) alongside the Building Blocks trial (over 2.5\u00a0y). The analysis was conducted in accordance with National Institute for Health and Clinical Excellence (NICE) reference case standards. Health\u2010related quality of life was elicited from mothers using the EQ\u20105D\u20103L. Resource\u2010use data were collected from self\u2010reported questionnaires, Hospital Episode Statistics, general practitioner records and the central Department of Health FNP database. Costs and quality\u2010adjusted life years (QALYs) were discounted at 3.5%. The base case analysis used an intention to treat approach on the imputed dataset using multiple imputation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The FNP intervention costs on average \u00a31812 more per participant compared to usual care (95% confidence interval: \u2212\u00a32700; \u00a35744). Incremental adjusted mean QALYs are marginally higher for FNP (mean difference 0.0036, 95% confidence interval: \u22120.017; 0.025). The probability of FNP being cost\u2010effective is less than 20% given the current NICE willingness to pay threshold of \u00a320\u00a0000 per additional QALY. The results were robust to sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given the absence of significant benefits of FNP in terms of the primary outcomes of the trial and only marginal maternal QALY gains, FNP does not represent a cost\u2010effective intervention when compared with existing services already offered to young pregnant women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jep.12799","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T05:17:44Z","timestamp":1502428664000},"page":"1367-1374","source":"Crossref","is-referenced-by-count":24,"title":["Cost\u2010effectiveness of the Family Nurse Partnership (FNP) programme in England: Evidence from the building blocks trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-0379","authenticated-orcid":false,"given":"Belen","family":"Corbacho","sequence":"first","affiliation":[{"name":"York Trials Unit, Department of Health Sciences University of York  York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-138X","authenticated-orcid":false,"given":"Kerry","family":"Bell","sequence":"additional","affiliation":[{"name":"York Trials Unit, Department of Health Sciences University of York  York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4905-3704","authenticated-orcid":false,"given":"Eugena","family":"Stamuli","sequence":"additional","affiliation":[{"name":"York Trials Unit, Department of Health Sciences University of York  York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2360-4566","authenticated-orcid":false,"given":"Gerry","family":"Richardson","sequence":"additional","affiliation":[{"name":"Centre for Health Economics University of York  York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8321-786X","authenticated-orcid":false,"given":"Sarah","family":"Ronaldson","sequence":"additional","affiliation":[{"name":"York Trials Unit, Department of Health Sciences University of York  York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5268-8631","authenticated-orcid":false,"given":"Kerenza","family":"Hood","sequence":"additional","affiliation":[{"name":"Centre for Trials Research Cardiff University Neuadd Meirionnydd  Health Park Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-9989","authenticated-orcid":false,"given":"Julia","family":"Sanders","sequence":"additional","affiliation":[{"name":"School of Healthcare Sciences  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1004-036X","authenticated-orcid":false,"given":"Michael","family":"Robling","sequence":"additional","affiliation":[{"name":"Centre for Trials Research Cardiff University Neuadd Meirionnydd  Health Park Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1667-4275","authenticated-orcid":false,"given":"David","family":"Torgerson","sequence":"additional","affiliation":[{"name":"York Trials Unit, Department of Health Sciences University of York  York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"On behalf of the Building Blocks trial group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550080054039"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2013.08.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.77.1.16"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.3.486"},{"key":"e_1_2_8_6_1","unstructured":"BarnesJ.Nurse\u2010family partnership programme: first year pilot site implementation in England: pregnancy and the post\u2010partum period;2008"},{"key":"e_1_2_8_7_1","unstructured":"BarnesJ.Nurse\u2010family partnership programme second year pilot sites implementation in England the infancy period;2009"},{"key":"e_1_2_8_8_1","unstructured":"BarnesJ BallM MeadowsP et al.The Family\u2010Nurse Partnership programme in England: wave 1 implementation in toddlerhood and a comparison between waves 1 and 2a of implementation in pregnancy and infancy;2011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-114"},{"key":"e_1_2_8_10_1","unstructured":"Policy Research Programme Project D. o. 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