{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:04:19Z","timestamp":1783533859137,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","award":["2603949255"],"award-info":[{"award-number":["2603949255"]}],"id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale, aims, and objectives<\/jats:title><jats:p>Despite recommendations in prevailing guidelines to avoid the use of non\u2010selective (NS) \u03b2\u2010blockers in patients with asthma or COPD, on average, 10 patients per community pharmacy receive NS \u03b2\u2010blockers monthly. The aim of our study was to identify the reasons of prescribers and pharmacists to treat asthma and COPD patients with NS \u03b2\u2010blockers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010three community pharmacists in the Netherlands selected patients with actual concurrent use of inhalation medication and NS \u03b2\u2010blockers. For at least 5 patients, each pharmacist screened all medication surveillance signals and actions taken at first dispensing. Each pharmacist selected 3 different initial prescribers for a short interview to explore their awareness of the co\u2010morbidity and reasons to apply NS \u03b2\u2010blockers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pharmacists identified 827 asthma\/COPD patients with actual use of NS \u03b2\u2010blockers. From these, 153 NS \u03b2\u2010blocker prescribers were selected and interviewed (64 general practitioners, 45 ophthalmologists, 24 cardiologists, and 20 other prescribers). One hundred seven prescribers were aware of the drug\u2010disease interaction of the asthma or COPD co\u2010morbidity when initiating the NS \u03b2\u2010blocker, and 46 were not. From these, 40 prescribers did not consider the contraindication to be relevant.<\/jats:p><jats:p>For 299 patients, medication surveillance signals and actions at first dispensing were retrieved. Patients used predominantly ocular timolol (39.8%), and the oral preparations propranolol (30.8%) and carvedilol (15.1%). In 154 cases, the pharmacy system generated a warning alert.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A substantial number of prescribers was unaware of the co\u2010morbidity or did not regard NS \u03b2\u2010blockers contraindicated, despite prevailing clinical guidelines. Improvement programs should target prescribers' awareness and knowledge of NS \u03b2\u2010blockers in patients with asthma or COPD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jep.12869","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T16:15:17Z","timestamp":1515600917000},"page":"396-402","source":"Crossref","is-referenced-by-count":9,"title":["Considerations of prescribers and pharmacists for the use of non\u2010selective \u03b2\u2010blockers in asthma and <scp>COPD<\/scp> patients: An explorative study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0316-1278","authenticated-orcid":false,"given":"Esther","family":"Kuipers","sequence":"first","affiliation":[{"name":"Department of IQ Healthcare, Radboud Institute for Health Sciences Radboud University Medical Centre  Nijmegen The Netherlands"},{"name":"BENU Apotheek Zeist West  Zeist The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Wensing","sequence":"additional","affiliation":[{"name":"Department of IQ Healthcare, Radboud Institute for Health Sciences Radboud University Medical Centre  Nijmegen The Netherlands"},{"name":"Department of General Practice and Health Services Research University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.G.M.","family":"De Smet","sequence":"additional","affiliation":[{"name":"Department of IQ Healthcare, Radboud Institute for Health Sciences Radboud University Medical Centre  Nijmegen The Netherlands"},{"name":"Department of Clinical Pharmacy, Radboud Institute for Health Sciences Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-3325","authenticated-orcid":false,"given":"Martina","family":"Teichert","sequence":"additional","affiliation":[{"name":"Department of IQ Healthcare, Radboud Institute for Health Sciences Radboud University Medical Centre  Nijmegen The Netherlands"},{"name":"Department of Clinical Pharmacy &amp; Toxicology Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"NHG. 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