{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:13:22Z","timestamp":1790374402692,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:00:00Z","timestamp":1524787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Functional magnetic resonance imaging (fMRI) is used widely to study reorganization after early brain injuries. Unilateral cerebral palsy (UCP) is an appealing model for studying brain plasticity by fMRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To summarize the results of task\u2010related fMRI studies in UCP in order to get better understanding of the mechanism of neuroplasticity of the developing brain and its reorganization potential and better translation of this knowledge to clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted on the PubMed database by keywords: \u201ccerebral palsy\u201d, \u201ccongenital hemiparesis\u201d, \u201cunilateral\u201d, \u201cMagnetic resonance imaging\u201d , \u201cfMRI\u201d, \u201creorganization\u201d, and \u201cplasticity\u201d The exclusion criteria were as follows: case reports; reviews; studies exploring non\u2010UCP patients; and studies with results of rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found 7 articles investigated sensory tasks; 9 studies\u2014motor tasks; 12 studies\u2014speech tasks. Ipsilesional reorganization is dominant in sensory tasks (in 74\/77 patients), contralesional\u2014in only 3\/77. In motor tasks, bilateral activation is found in 64\/83, only contralesional\u2014in 11\/83, and only ipsilesional\u20148\/83. Speech perception is bilateral in 35\/51, only or dominantly ipsilesional (left\u2010sided) in 8\/51, and dominantly contralesional (right\u2010sided) in 8\/51. Speech production is only or dominantly contralesional (right\u2010sided) in 88\/130, bilateral\u201426\/130, and only or dominantly ipsilesional (left\u2010sided)\u2014in 16\/130.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The sensory system is the most \u201crigid\u201d to reorganization probably due to absence of ipsilateral (contralesional) primary somatosensory representation. The motor system is more \u201cflexible\u201d due to ipsilateral (contralesional) motor pathways. The speech perception and production show greater flexibility resulting in more bilateral or contralateral activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The models of reorganization are variable, depending on the development and function of each neural system and the extent and timing of the damage. The plasticity patterns may guide therapeutic intervention and prognostics, thus proving the fruitiness of the translational approach in neurosciences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jep.12929","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T03:01:14Z","timestamp":1524798074000},"page":"839-850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Task\u2010related fMRI in hemiplegic cerebral palsy\u2014A systematic review"],"prefix":"10.1111","volume":"24","author":[{"given":"Katerina","family":"Gaberova","sequence":"first","affiliation":[{"name":"Department of Pediatrics St. George University Hospital  Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0461-9065","authenticated-orcid":false,"given":"Iliyana","family":"Pacheva","sequence":"additional","affiliation":[{"name":"Department of 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