{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:07:02Z","timestamp":1785510422125,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An association between allergic rhinitis (AR) and digestive diseases (DDs) has been reported; however, studies have only focused on the prevalence of DDs in populations of patients with AR. In individuals with specific DDs, the impact of AR on the frequency of clinical visits for each DD has not been studied. Moreover, the association between topical steroid usage for AR and DDs has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 16\u00a0526 men and 18\u00a0438 women, aged 21 to 30\u00a0years, were collected from a national database. Individuals were separated into the AR and non\u2010AR groups. Eight common DDs were studied: (1) gastroesophageal reflux disease (GERD), (2) gastritis and duodenitis, (3) peptic ulcers, (4) irritable bowel syndrome, (5) gastric functional disease, (6) intestinal functional disease, (7) gastroenteritis and colitis, and (8) constipation. The rate of each DD was compared between groups. In individuals with specific DDs, the frequency of clinical visits for each DD was also compared between groups. Between users and nonusers of topical steroids in the AR group, the rate of DDs was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant associations were observed between all eight DDs and AR in both sexes. In comparison to the non\u2010AR group, women with AR visited clinics more frequently for gastritis\/duodenitis, gastric and intestinal functional disease, gastroenteritis\/colitis, and constipation, while men with AR visited clinics more frequently for gastritis\/duodenitis, gastric functional disease, gastroenteritis\/colitis, and constipation. Female topical\u2010steroid users with AR had higher rates of GERD, irritable bowel syndrome, gastric or intestinal functional disease, and gastritis\/colitis. Male topical\u2010steroid users with AR had higher rates of GERD and peptic ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AR was associated with DDs in both sexes. However, the influence of AR on clinical visit frequency varied among specific DD groups. Topical steroid usage for AR was associated with some DDs, but the association requires future evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jep.13108","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T07:38:44Z","timestamp":1550475524000},"page":"242-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The impact of allergic rhinitis on gastrointestinal disorders among young adults"],"prefix":"10.1111","volume":"26","author":[{"given":"Sai\u2010Wai","family":"Ho","sequence":"first","affiliation":[{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Department of Emergency Medicine Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Pin","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Microbiology and Immunology Chung Shan Medical University  Taichung Taiwan"},{"name":"Division of Gastroenterology, Department of Internal Medicine Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-4372","authenticated-orcid":false,"given":"Min\u2010Sho","family":"Ku","sequence":"additional","affiliation":[{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Division of Allergy, Asthma and Rheumatology, Department of Pediatrics Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.050"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.049585"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12846"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60404-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.05.018"},{"key":"e_1_2_9_7_1","unstructured":"Would you have Allergic Rhinitis when you have Gastric Ulcer? http:\/\/www.ehealthme.com\/cs\/gastric%20ulcer\/allergic%20rhinitis\/."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489611"},{"key":"e_1_2_9_9_1","first-page":"1","volume-title":"National Health Insurance Evaluation and Projections","author":"Department of health, E. 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