{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:11:05Z","timestamp":1784628665065,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale, aims and objectives<\/jats:title><jats:p>Approximately 20\u2009000 cases of septic arthritis (SA) occur in the U.S. yearly. We examined whether gender\u2010related differences exist in the presentation, management, and outcomes of patients with native joint septic arthritis (NJSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of medical files of patients aged 18\u2009years and older admitted between 1998 and 2015 to a single tertiary care hospital and diagnosed with NJSA. All study subjects had positive synovial fluid or blood cultures and each was managed surgically. Patients\u2019 charts were reviewed for demographics, comorbidities, clinical presentations, microbiology profiles, management, and outcomes. Cases of osteomyelitis, septic bursitis, prosthetic joint, and culture\u2010negative SA were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 324 NJSA patients, those who were female (n = 130; 40.1%) were significantly older at presentation than males (mean age: 63.6 vs 58.3; <jats:italic>P<\/jats:italic> =\u2009.006). Prior joint pathology was more common amongst females, including osteoarthritis (20.8% vs 12.9%; <jats:italic>P<\/jats:italic> =\u2009.04) and rheumatoid arthritis (10% vs 3.6%; <jats:italic>P<\/jats:italic> =\u2009.03). Female patients had a higher frequency of hip involvement (17.7% vs 10.8%; <jats:italic>P<\/jats:italic> =\u2009.05). No differences were observed in clinical presentations, culture results, medical management, or outcomes between genders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared to men, women with NJSA presented at an older age and had more prior joint pathology and a higher frequency of hip involvement. These differences, however, had no significant impact on the clinical presentation, medical management, or outcomes of NJSA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jep.13437","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T06:32:03Z","timestamp":1593671523000},"page":"371-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The impact of gender on the clinical presentation, management, and surgical outcomes of patients with <scp>native\u2010joint<\/scp> septic arthritis"],"prefix":"10.1111","volume":"27","author":[{"given":"Lior","family":"Nissim","sequence":"first","affiliation":[{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah B.","family":"Lieber","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9777-2864","authenticated-orcid":false,"given":"Mohammad E.","family":"Naffaa","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"},{"name":"Department of Rheumatology Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Louise","family":"Fowler","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Shmerling","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3688-2581","authenticated-orcid":false,"given":"Ziv","family":"Paz","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"},{"name":"Department of Rheumatology Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Rheumatology Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7]]},"reference":[{"issue":"8","key":"e_1_2_8_2_1","first-page":"540","article-title":"Study of 112 patients with septic arthritis caused by pyogenic organisms and fungi: changes in the clinical spectrum during the last 2 decades","volume":"197","author":"Val del Amo N","year":"1997","journal-title":"Rev Clin 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