{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T22:10:27Z","timestamp":1766182227121,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale<\/jats:title><jats:p>Prescription opioid use and misuse have increased rapidly in many Western countries in the past decade. Patients (mis)using opioids are at risk of presenting to the emergency department (ED) with opioid\u2010related problems. European data concerning prescription opioid (mis)use among the ED population is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims and Objectives<\/jats:title><jats:p>This study aims to determine prevalence of prescription opioid use, misuse, and opioid use disorder (OUD) among Dutch ED patients. Secondary objectives were to explore factors associated with prescription opioid misuse and the number of patients discharged with a new opioid prescription.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional multicenter study at three hospitals in the Netherlands, adult ED patients were screened for current prescription opioid use. Opioid users filled out questionnaires regarding opioid (mis)use, and underwent a structured interview to assess OUD criteria. The primary outcomes were prevalence rates of (1) current prescription opioid use, (2) prescription opioid misuse (based on a Current Opioid Misuse Measure [COMM]\u00a0score\u2009&gt;\u20098), (3) OUD, based on DSM\u20105 criteria. Independent <jats:italic>T<\/jats:italic>\u2010tests, Pearson <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> and Fisher's Exact tests were used to analyse differences in characteristics between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 997 patients were screened, of which 15% (<jats:italic>n<\/jats:italic>\u2009=\u2009150) used prescription opioids. Out of 93 patients assessed, 22.6% (<jats:italic>n<\/jats:italic>\u2009=\u200921) showed signs of prescription opioid misuse, and 9.8% (<jats:italic>n<\/jats:italic>\u2009=\u20099, 95%\u00a0CI: 4.5\u201317.8) fulfilled criteria for OUD. A medical history of psychiatric disorder was significantly more common in patients with prescription opioid misuse and OUD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that prescription opioid use is relatively common in ED patients in the Netherlands, compared to the overall population. Over one fifth of these patients shows signs of opioid misuse or OUD. Awareness among ED personnel about the high prevalence of prescription opioid (mis)use in their population is critical for signalling opioid\u2010related problems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jep.13965","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T13:29:15Z","timestamp":1705930155000},"page":"473-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The prevalence of prescription opioid use and misuse among\u00a0emergency department\u00a0patients in The Netherlands"],"prefix":"10.1111","volume":"30","author":[{"given":"Joris","family":"Holkenborg","sequence":"first","affiliation":[{"name":"Emergency Department Rijnstate Hospital Arnhem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernice A.","family":"Frenken","sequence":"additional","affiliation":[{"name":"Emergency Department Rijnstate Hospital Arnhem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte van de Kerkhof\u2010Van","family":"Bon","sequence":"additional","affiliation":[{"name":"Emergency Department Canisius Wilhelmina Hospital Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice P.","family":"Vroegop","sequence":"additional","affiliation":[{"name":"Emergency Department Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariska G. 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