{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:18:03Z","timestamp":1771312683452,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As the elderly population continues to grow worldwide, it becomes crucial to explore safe and effective treatment options to manage venous thromboembolic disease in this vulnerable demographic group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We carried out a retrospective cohort study (January 2017\u2013December\u00a02021) to analyse the efficacy and safety of bemiparin as a treatment for venous thromboembolic disease in 223 patients. We compared patients aged \u226565 years (elderly;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009153) with patients aged less than 65 years (adults;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200970) for a combined end point of death, recurrent thromboembolism, and major bleeding at 30 days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Elderly (mean age 79\u2009\u00b1\u20097.7 years) and adult patients (mean age 51.5\u2009\u00b1\u200911.6 years) received similar bemiparin doses 8470\u2009\u00b1\u20092362 International units (IU)\/d versus 8754\u2009\u00b1\u20091593 IU\/d, during a similar median [Interquartile range] period of 28 [9\u2013118] versus 30 [10\u201390] days, respectively. At 30\u2010day follow up a total of 24 elderly patients (15.7%), reached at least one of the end points, as compared with six adult patients (8.6%) (absolute difference 7.1%; 95% confidence interval [95%\u00a0CI], \u22121.6 to 15.8). Recurrence of venous thromboembolic disease occurred in five elderly patients (3.3%) and in five adult patients (7.1%) (absolute difference \u22123.9%; 95%\u00a0CI, \u221210.5 to 2.8).\u00a0There were two episodes of major bleeding each in elderly (1.3%) and adult (2.9%) patients (absolute difference \u22121.6%; 95% CI, \u22125.8 to 2.7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bemiparin showed a similar efficacy and safety profile in the treatment of venous thromboembolic disease in elderly and adult patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jep.14025","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T03:24:01Z","timestamp":1716780241000},"page":"1084-1090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of bemiparin as treatment of venous thromboembolic disease in the elderly"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1181-7396","authenticated-orcid":false,"given":"Javier","family":"Ena","sequence":"first","affiliation":[{"name":"Department of Medicine Hospital Marina Baixa Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvena","family":"Stanimirova\u2010Nikolova","sequence":"additional","affiliation":[{"name":"Department of Medicine Hospital Marina Baixa Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Iborra\u2010Devesa","sequence":"additional","affiliation":[{"name":"Department of Medicine Hospital Marina Baixa Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Raya\u2010Santos","sequence":"additional","affiliation":[{"name":"Department of Medicine Hospital Marina Baixa Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"Serra\u2010Manclus","sequence":"additional","affiliation":[{"name":"Department of Medicine Hospital Marina Baixa Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio J.","family":"Seco\u2010Hanselaar","sequence":"additional","affiliation":[{"name":"Department of Medicine Hospital Marina Baixa Alicante 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