{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:51:45Z","timestamp":1787165505439,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous and multisystem disease with potential impact on health\u2010related quality of life (HRQoL). Understanding the burden and determinants of poor HRQoL in COPD may highlight modifiable factors that could minimize disease impact among an already vulnerable population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the HRQoL and its determinants among COPD patients attending a tertiary care hospital in Lagos, Nigeria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross\u2010sectional study conducted at the Lagos University Teaching Hospital, Lagos, Nigeria. Participants with stable COPD were recruited and sociodemographic and clinical characteristics, current medications, and comorbidities were obtained. The HRQoL was assessed using the St. Georges Respiratory Questionnaire COPD version (SGRQ\u2010C), functional status was assessed by the 6\u2010min walk test (6MWT) and mortality risk assessed using the BODE index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty\u2010three participants were recruited and 47 (56.6%) were male. COPD assessment test (CAT) score was \u2265\u200910 in 81 (97.6%) participants and 47 (56.6%) had Modified Medical Research Council Dyspnea (mMRC) grading \u2265\u20092. The median 6\u2010min walk distance (6MWD) was 256.0 meters (IQR\u2009=\u200993.0) and median BODE index was 4.0 (IQR\u2009=\u20093.0). Most of the participants (72) had 6MWD of &lt;\u2009350 meters, 22 had a BODE index score of &gt;\u20095 and only 1 participant scored &gt;\u20097. The median total SGRQ score was 47.7 (39.6\u201352.8) and the symptoms domain had the worst score of 76.7 (65.9\u201388.3). Factors that independently worsened HRQoL are higher CAT and MRC scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HRQoL is substantially impaired in COPD in our practice setting. High symptoms burden and worsening dyspnea worsened HRQoL. Interventions that reduce the burden of dyspnea and other symptoms such as pulmonary rehabilitation is a potential high value intervention in our setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jep.70178","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T02:52:53Z","timestamp":1750733573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Determinants of Health\u2010Related Quality of Life Among COPD Patients From a Clinical Practice Setting in Nigeria"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-094X","authenticated-orcid":false,"given":"Abiodun G.","family":"Tekobo","sequence":"first","affiliation":[{"name":"Department of Medicine Federal Teaching Hospital Katsina Katsina City Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tochukwu T.","family":"Ayo\u2010Olagunju","sequence":"additional","affiliation":[{"name":"Department of Medicine Lagos University Teaching Hospital Surulere Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adewale","family":"Ogundare","sequence":"additional","affiliation":[{"name":"Department of Medicine Lagos University Teaching Hospital Surulere Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle G.","family":"Dania","sequence":"additional","affiliation":[{"name":"Department of Medicine Lagos University Teaching Hospital Surulere Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taofeek","family":"Oloyede","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal Teaching Hospital Katsina Katsina City Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akintayo T.","family":"Olaniyan","sequence":"additional","affiliation":[{"name":"Department of Demography and Social Statistics Obafemi Awolowo University Ile\u2010Ife Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufemi O.","family":"Ojo","sequence":"additional","affiliation":[{"name":"Department of Medicine Lagos State University Teaching Hospital Ikeja Nigeria"},{"name":"Department of Medicine Lagos State University College of Medicine Ikeja Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope","family":"Fapohunda","sequence":"additional","affiliation":[{"name":"Department of Medicine Lagos State University Teaching Hospital Ikeja Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ogochukwu A.","family":"Ekete","sequence":"additional","affiliation":[{"name":"Department of Medicine Lagos University Teaching Hospital Surulere Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufunke O.","family":"Adeyeye","sequence":"additional","affiliation":[{"name":"Department of Medicine Lagos State University Teaching Hospital Ikeja Nigeria"},{"name":"Department of Medicine Lagos State University College of Medicine Ikeja Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7865-4771","authenticated-orcid":false,"given":"Obianuju B.","family":"Ozoh","sequence":"additional","affiliation":[{"name":"Department of Medicine Lagos University Teaching Hospital Surulere Nigeria"},{"name":"Department of Medicine, College of Medicine Lagos State University Ikeja Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"issue":"5","key":"e_1_2_7_2_1","first-page":"1","article-title":"Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: The GOLD Committee Report 2019","volume":"53","author":"Augusti A.","year":"2019","journal-title":"European Respiratory Journal"},{"issue":"138","key":"e_1_2_7_3_1","first-page":"1","article-title":"Predictive Factors Over Time of Health Related Quality of Life in COPD Patient","volume":"21","author":"Crist\u00f3bal E.","year":"2020","journal-title":"Respiratory Research"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.07.89"},{"issue":"9","key":"e_1_2_7_5_1","first-page":"218","article-title":"Health\u2010Related Quality of Life\u2014An Introduction","volume":"13","author":"Khanna D.","year":"2007","journal-title":"American Journal of Managed Care"},{"key":"e_1_2_7_6_1","unstructured":"V. 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