{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T13:58:11Z","timestamp":1785592691747,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005668","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","doi-asserted-by":"publisher","award":["2812024"],"award-info":[{"award-number":["2812024"]}],"id":[{"id":"10.13039\/501100005668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cardiovascular and cerebrovascular diseases are projected to expand in the coming decades as the main cause of death. This study outlines the escalating burden of cardiovascular diseases in low\u2010 and middle\u2010income countries (LMICs), particularly in Latin America (LA), which is expected to surpass that of other high\u2010population regions. Despite advances in prevention strategies, adherence to therapeutic goals remains a global challenge, especially in LMICs where control rates are notably low for conditions such as hypertension, type 2 diabetes mellitus (DM2), and dyslipidemia. Emerging evidence from LMICs supports the feasibility and effectiveness of telehealth interventions for cardiometabolic disease management in primary care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To address these challenges, a remote chronic disease management program has been developed to optimize risk factor control through standardized medical protocols and task automation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is an open\u2010label randomized and decentralized clinical trial describing the design and methodology of the TAMIS program, which will assess its impact on community\u2010dwelling diabetic subjects with uncontrolled HBA1c and uncontrolled LDL\u2010C and\/or blood pressure. Individuals will be randomized to usual care or remote care and followed for 84 weeks. Remote monitoring offers a practical response to the limited capacity of LMIC health systems to ensure sustained follow\u2010up and continuity of care for chronic conditions. The primary endpoint is a win\u2010ratio of hierarchical events, including all\u2010cause deaths and the frequency of all\u2010cause hospitalizations. The secondary endpoints include control of HbA1c, LDL\u2010C and blood pressure according to clinical guidelines, as well as patient\u2010reported outcomes and clinical parameters, including blood pressure, glycemic control, and LDL cholesterol levels. Subgroup analyses will explore the impact of demographics and clinical characteristics on treatment outcomes. Overall, the study aims to improve health care delivery, enhance patient education, and foster collaboration between patients and health care providers to mitigate the growing burden of cardiovascular diseases in LMICs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jep.70456","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:06:51Z","timestamp":1777468011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Remote Chronic Disease Management Program to Improve Cardiovascular and Metabolic Outcomes in a Diverse Community\u2010Based Diabetic Population: Study Design of the TAMIS Trial"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7950-1443","authenticated-orcid":false,"given":"Renato de Carvalho","family":"Barros","sequence":"first","affiliation":[{"name":"Data Laboratory for Research on Quality of Care and Outcomes (LaDaQCOR) Catholic University of Bras\u00edlia (UCB) Bras\u00edlia Brazil"},{"name":"Post\u2010Graduation Program in Medical Sciences University of Bras\u00edlia Bras\u00edlia Distrito Federal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Stephanus","sequence":"additional","affiliation":[{"name":"Data Laboratory for Research on Quality of Care and Outcomes (LaDaQCOR) Catholic University of Bras\u00edlia (UCB) Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio Barbosa","family":"Filho","sequence":"additional","affiliation":[{"name":"Data Laboratory for Research on Quality of Care and Outcomes (LaDaQCOR) Catholic University of Bras\u00edlia (UCB) Bras\u00edlia Brazil"},{"name":"Research Group on Cardiovascular Diseases of Bras\u00edlia, Higher School of Health Sciences (ESCS) University of the Federal District (UnDF) Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evellyn","family":"Mariana","sequence":"additional","affiliation":[{"name":"Data Laboratory for Research on Quality of Care and Outcomes (LaDaQCOR) Catholic University of Bras\u00edlia (UCB) Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmim","family":"Botelho","sequence":"additional","affiliation":[{"name":"Data Laboratory for Research on Quality of Care and Outcomes (LaDaQCOR) Catholic University of Bras\u00edlia (UCB) Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaiene M. M.","family":"Severino","sequence":"additional","affiliation":[{"name":"Data Laboratory for Research on Quality of Care and Outcomes (LaDaQCOR) Catholic University of Bras\u00edlia (UCB) Bras\u00edlia Brazil"},{"name":"Research Group on Cardiovascular Diseases of Bras\u00edlia, Higher School of Health Sciences (ESCS) University of the Federal District (UnDF) Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson Concei\u00e7\u00e3o","family":"Silva","sequence":"additional","affiliation":[{"name":"Data Laboratory for Research on Quality of Care and Outcomes (LaDaQCOR) Catholic University of Bras\u00edlia (UCB) Bras\u00edlia Brazil"},{"name":"Postgraduate Program in Physical Education (PPGEF) Catholic University of Bras\u00edlia (UCB) Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucila de Jesus","family":"Almeida","sequence":"additional","affiliation":[{"name":"Data Laboratory for Research on Quality of Care 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