{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:42:56Z","timestamp":1789454576610,"version":"build-2803163510"},"reference-count":160,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Artificial intelligence (AI) is rapidly transforming medicine through advanced diagnostic, prognostic, and decision\u2010support systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To summarize the fundamental concepts, clinical applications, ethical issues, and future perspectives of AI in healthcare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A narrative review of current evidence on machine learning, deep learning, neural networks, and AI applications across major medical specialties was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AI demonstrated high performance in diagnostic support, prognostic prediction, medical imaging, and personalized medicine. However, limitations related to data quality, generalizability, transparency, and ethical concerns remain significant challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AI has strong potential to improve healthcare delivery and precision medicine, although robust validation, ethical oversight, and appropriate regulation are essential for safe clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jep.70484","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T17:00:51Z","timestamp":1779814851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Artificial Intelligence in Medicine: Basic Knowledge, Applications, Ethics and Perspectives"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5236-3132","authenticated-orcid":false,"given":"Marco","family":"Cascella","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d University of Salerno Salerno Baronissi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Avella","sequence":"additional","affiliation":[{"name":"Centro Medico Legale di Lucca Istituto Nazionale Previdenza Sociale Lucca Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3037-0726","authenticated-orcid":false,"given":"Marcello Di","family":"Pumpo","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Public Health Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"},{"name":"Italian Society for Artificial Intelligence in Medicine (SIIAM) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Sebastiani","sequence":"additional","affiliation":[{"name":"Neuromuscular and Rare Disorders Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, NICU Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9566-9628","authenticated-orcid":false,"given":"Martino","family":"Bussa","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Tagliaferri","sequence":"additional","affiliation":[{"name":"Independent Researcher  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2694-905X","authenticated-orcid":false,"given":"Barbara","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Meloni","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Experimental Sciences University of Sassari Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bianchini","sequence":"additional","affiliation":[{"name":"Independent Researcher  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Graziani","sequence":"additional","affiliation":[{"name":"Independent Researcher  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Faustini","sequence":"additional","affiliation":[{"name":"Independent Researcher  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"D'Onofrio","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Locale di Pescara Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Manetta","sequence":"additional","affiliation":[{"name":"Independent Researcher  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Angela","family":"Catania","sequence":"additional","affiliation":[{"name":"Digital Healthcare SynbrAIn Via Giovacchino Belli Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Imbesi","sequence":"additional","affiliation":[{"name":"Independent Researcher  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Pane","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Sciences Center for Advanced Studies and Technology CAST \u201cG. d'Annunzio\u201d University of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Fusco","sequence":"additional","affiliation":[{"name":"Radiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. 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