{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:18:18Z","timestamp":1787815098373,"version":"build-2784847793"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n The 2026 global consensus proposal published in The Lancet renamed Polycystic Ovary Syndrome (PCOS) to Polyendocrine Metabolic Ovarian Syndrome (PMOS), replacing an anatomically misleading, cyst\u2010centered label with terminology grounded in the disorder's systemic endocrine\u2010metabolic nature. Although PMOS corrects a long\u2010standing mismatch between terminology and evidence, the philosophical, clinical, and social implications of this terminological shift have not been systematically examined.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To critically evaluate the transition from PCOS to PMOS through the lenses of medical nosology, philosophy of language, and Kazem Sadegh\u2010Zadeh's theory of fuzzy medical concepts, assessing both the scientific gains and the new epistemological, clinical, and social challenges introduced by the renaming.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This is a conceptual and interpretive analysis rather than an empirical study. Competing models of disease classification (anatomical, symptom\u2010based, eponymous, etiological, and mechanistic) are compared against the PMOS proposal. Sadegh\u2010Zadeh's analytic philosophy of medicine, particularly his account of fuzzy medical concepts, is applied to assess whether PMOS achieves genuine conceptual closure. The analysis draws on the original Lancet consensus statement, empirical reproductive\u2010outcome studies in PCOS, and a comparative precedent from the NAFLD\u2010to\u2010MASLD renaming, to evaluate clinical, psychological, and translatability implications.<\/jats:p>\n <\/jats:sec>\n \n Results\/Discussion<\/jats:title>\n While PMOS represents a substantial scientific improvement by shifting emphasis from anatomical appearance to the disorder's lifelong metabolic and cardiovascular risks\u2014including elevated odds of myocardial infarction and stroke\u2014it introduces new risks of biomedical reductionism, this time centered on metabolic markers rather than ovarian anatomy. Psychological and social dimensions of the syndrome, including anxiety, depression, and body image distress, remain linguistically invisible in the new name. Retention of the word \u201covarian,\u201d along with the acronym's phonetic proximity to \u201cPMS,\u201d risks re\u2010anchoring the condition to reproductive and gendered framings the renaming sought to escape. Applying Sadegh\u2010Zadeh's framework, PMOS is best understood as an inherently fuzzy construct whose boundaries resist complete biomedical closure, with implications for clinical ownership, multidisciplinary care coordination, cross\u2010cultural translatability, and the practical costs of transitioning established coding, literature, and patient\u2010identity systems.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n PMOS marks meaningful scientific progress in aligning medical language with the systemic reality of the disorder, yet it is not a definitive terminological solution. Lasting semantic stability requires nomenclature that remains responsive to the multidimensional, lived experience of patients. The shift from PCOS to PMOS should therefore be understood not merely as a linguistic correction but as an ongoing reconstruction of disease ontology itself.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jep.70545","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:26:42Z","timestamp":1785868002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Cysts to Metabolism: Trading Metaphors in Medical Language for the Polycystic Ovary Syndrome to Polyendocrine Metabolic Ovarian Syndrome Shifts"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7761-7787","authenticated-orcid":false,"given":"Fateme","family":"Derijani","sequence":"first","affiliation":[{"name":"Medical Ethics and History of Medicine Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Namazi","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics, Medical Ethics and History of Medicine Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9502-4694","authenticated-orcid":false,"given":"Vahid Ehsanian","family":"Mofrad","sequence":"additional","affiliation":[{"name":"Medical Ethics and History of Medicine Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(26)00717-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11019-022-10117-9"},{"key":"e_1_2_9_4_1","volume-title":"Making Sense of Illness: Science, Society, and Disease","author":"Aronowitz R. A.","year":"1998"},{"key":"e_1_2_9_5_1","volume-title":"WHO Best Practices for the Naming of New Human Infectious Diseases","author":"World Health Organization","year":"2015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-9579-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5935\/1518-0557.20240095"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5935\/1518-0557.20250040"},{"key":"e_1_2_9_9_1","volume-title":"Gender Trouble: Feminism and the Subversion of Identity","author":"Butler J.","year":"1990"},{"key":"e_1_2_9_10_1","volume-title":"Sexing the Body: Gender Politics and the Construction of Sexuality","author":"Fausto\u2010Sterling A.","year":"2000"},{"key":"e_1_2_9_11_1","volume-title":"The Woman in the Body: A Cultural Analysis of Reproduction","author":"Martin E.","year":"1987"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2024.101066"}],"container-title":["Journal of Evaluation in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jep.70545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jep.70545","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jep.70545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:33:50Z","timestamp":1787812430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jep.70545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/jep.70545"],"URL":"https:\/\/doi.org\/10.1111\/jep.70545","archive":["Portico"],"relation":{},"ISSN":["1356-1294","1365-2753"],"issn-type":[{"value":"1356-1294","type":"print"},{"value":"1365-2753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70545"}}