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This study mapped placebo and nocebo research in pain, distinguishing mechanistic studies from randomised controlled trials (RCTs), using data from the Web of Science Core Collection up to March 2025, which yielded 1246 mechanistic studies and 35,134 RCTs. Analyses performed with the Bibliometrix R package included descriptive statistics, co\u2010citation and keyword co\u2010occurrence networks, and local citations to assess internal impact. Mechanistic studies grew 3.97% annually, focusing on expectation, conditioning, and pain modulation, with key contributions from Benedetti, Colloca, and Wager, concentrated in the USA, Germany, Italy, and the UK. RCTs grew 3.52% per year, emphasising systematic reviews and methodological standards (Jadad scale, PRISMA), led by Moore and Manchikanti, with the USA, China, and the UK dominating output. Co\u2010citation analyses identified mechanistic clusters around opioidergic and dopaminergic pathways and prefrontal\u2013cingulate circuits, and RCT clusters emphasising methodological rigour and pain outcomes. Keyword analyses highlighted pain, analgesia, and expectation as central themes, with emerging trends reflecting evolving clinical applications and innovative trial designs. This scientometric mapping underscores the dual role of placebo as a neurobiological phenomenon and methodological cornerstone, offering a comprehensive overview of the evolution, structure, and thematic organisation of placebo and nocebo research in pain.<\/jats:p>","DOI":"10.1111\/jep.70570","type":"journal-article","created":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T17:56:42Z","timestamp":1789322202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive Scientometric Analysis of Placebo and Nocebo Effects in Pain Research: From Placebo Mechanisms to Clinical Trials"],"prefix":"10.1111","volume":"32","author":[{"given":"Francesca","family":"Borghesi","sequence":"first","affiliation":[{"name":"Department of Psychology University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0974-371X","authenticated-orcid":false,"given":"Valeria","family":"Volpino","sequence":"additional","affiliation":[{"name":"\u201cRita Levi Montalcini\u201d Department of Neurosciences University of Turin Turin Italy"},{"name":"Carlo Molo Foundation Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8388-3403","authenticated-orcid":false,"given":"Elisa","family":"Rho","sequence":"additional","affiliation":[{"name":"\u201cRita Levi Montalcini\u201d Department of Neurosciences University of Turin Turin Italy"},{"name":"Carlo Molo Foundation Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7780-104X","authenticated-orcid":false,"given":"Giorgia","family":"Cecconato","sequence":"additional","affiliation":[{"name":"\u201cRita Levi Montalcini\u201d Department of Neurosciences University of Turin Turin Italy"},{"name":"Carlo Molo Foundation Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1356-8271","authenticated-orcid":false,"given":"Francesco","family":"Campaci","sequence":"additional","affiliation":[{"name":"\u201cRita Levi Montalcini\u201d Department of Neurosciences University of Turin Turin Italy"},{"name":"Carlo Molo Foundation Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Cipresso","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5705-2173","authenticated-orcid":false,"given":"Alessandro","family":"Piedimonte","sequence":"additional","affiliation":[{"name":"\u201cRita Levi Montalcini\u201d Department of Neurosciences University of Turin Turin Italy"},{"name":"Carlo Molo Foundation Turin Italy"},{"name":"Istituto Auxologico Italiano IRCCS, U.O. di Neurologia e Neuroriabilitazione Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8472-656X","authenticated-orcid":false,"given":"Elisa","family":"Carlino","sequence":"additional","affiliation":[{"name":"\u201cRita Levi Montalcini\u201d Department of Neurosciences University of Turin Turin Italy"},{"name":"Istituto Auxologico Italiano IRCCS, U.O. di Neurologia e Neuroriabilitazione Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2020.03.028"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.48.113006.094711"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04169-6"},{"key":"e_1_2_11_5_1","first-page":"649","article-title":"The Placebo Response: Recent Research and Implications for Family Medicine","volume":"49","author":"Brody H.","year":"2000","journal-title":"Journal of Family Practice"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61706-2"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","unstructured":"D. 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