{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:48:05Z","timestamp":1791830885912,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale, Aims and Objectives<\/jats:title>\n                    <jats:p>A validated rule\u2010out instrument can turn the collective absence of warning findings into an explicit warrant for stopping a specified diagnostic inquiry. This paper characterises that inversion in clinical use and asks whether \u2018red flag\u2019 adequately distinguishes it from using positive signs to pursue suspected lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Comparative conceptual analysis of the clinical sign, exemplified by Babinski's plantar response, and the Ottawa Subarachnoid Hemorrhage Rule. The Clinical Standards Advisory Group (CSAG) back\u2010pain guidance and SNNOOP10 headache checklist are examined as heterogeneous comparators. Five objections test the argument, including its compatibility with Bayesian reasoning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The inversion concerns intended clinical use and the direction of licensed action, rather than an intrinsic direction of inference determined by sensitivity or specificity. Ottawa provides the paradigm case: within its defined eligible population, absence of all criteria can support foregoing further investigation for subarachnoid haemorrhage. A positive result does not establish the diagnosis, and the composite rule's low specificity does not make every constituent criterion uninformative. Three consequences follow: licensed action can shift from pursuit to stopping; epistemic authority is partly redistributed toward validated thresholds; and negative findings can provide a shared justification for closing a specified diagnostic pathway. Clinical judgement remains necessary throughout. Resource consequences should be distinguished from rationing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The distinctive object is a decision architecture connecting evidence to permission not to investigate. Its limits become clearer when validated rule\u2010out instruments are distinguished from mixed warning checklists and their practical function is separated from their probabilistic properties.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jep.70674","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:29:05Z","timestamp":1791829745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Inverted Sign: Rule\u2010In, Rule\u2010Out, and the Epistemology of the Red Flag"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4558-1059","authenticated-orcid":false,"given":"Albert","family":"Gr\u00fcger","sequence":"first","affiliation":[{"name":"GLG Martin Gropius Krankenhaus Eberswalde Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.05.028"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278018"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.170072"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-119-9-199311010-00012"},{"key":"e_1_2_12_6_1","volume-title":"Clinical Methods: The History, Physical, and Laboratory Examinations","author":"Walker H. 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