{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:32:56Z","timestamp":1790555576067,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this systematic review and meta\u2010analysis was to evaluate the soft tissue outcomes of connective tissue graft (CTG) combined with immediate implant placement and restoration (IIPR) in the esthetic zone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Following the guidelines of Preferred Reporting Items for Systematic Reviews and Meta\u2010analyses (PRISMA) statement, randomized controlled trials (RCTs) were searched for in electronic databases and complemented by hand searching. The risk of bias was assessed using the Cochrane Collaboration's Risk of Bias tool and data were analyzed using statistical software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 180 studies were identified, of which, four trials were included with 144 implant sites in 144 participants. Overall meta\u2010analysis showed that CTG in conjunction with IIPR had a significantly greater gingival thickness than IIPR alone. The IIPR with CTG had less recession and higher esthetic pink score compared to IIPR group, but the difference was not statistically significant. No significant differences in implant failure rate were found between IIPR with and without CTG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of CTG in conjunction with IIPR in the esthetic zone significantly improved the thickness of the gingival tissues compared to IIPR without CTG. No significant differences were observed in the level of soft tissues around immediately placed implants with or without CTG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>The use of connective tissue graft with IIPR can be considered to improve the soft tissue profile and minimize mucosal recession in esthetic zone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jerd.12538","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T16:14:46Z","timestamp":1572884086000},"page":"280-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Soft tissue changes after connective tissue grafts around immediately placed and restored dental implants in the esthetic zone: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4019-9491","authenticated-orcid":false,"given":"Momen A.","family":"Atieh","sequence":"first","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Healthcare City  Dubai United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeel H. M.","family":"Alsabeeha","sequence":"additional","affiliation":[{"name":"Ras Al\u2010Khaimah Dental Center, Ministry of Health  Ras Al\u2010Khaimah United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"378","article-title":"Immediate loading with single implant crowns: a systematic review and meta\u2010analysis","volume":"22","author":"Atieh MA","year":"2009","journal-title":"Int J Prosthodont"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01725.x"},{"key":"e_1_2_8_4_1","first-page":"401","article-title":"Immediate placement or immediate restoration\/loading of single implants for molar tooth replacement: a systematic review and meta\u2010analysis","volume":"25","author":"Atieh MA","year":"2010","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_5_1","first-page":"186","article-title":"Clinical and esthetic outcomes of implants placed in postextraction sites","volume":"24","author":"Chen ST","year":"2009","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01748.x"},{"key":"e_1_2_8_7_1","first-page":"11","article-title":"Stability of the mucosal topography around single\u2010tooth implants and adjacent teeth: 1\u2010year results","volume":"20","author":"Grunder U","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_8_1","first-page":"31","article-title":"Immediate placement and provisionalization of maxillary anterior single implants: 1\u2010year prospective study","volume":"18","author":"Kan JY","year":"2003","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_9_1","first-page":"274","article-title":"A short\u2010term clinical evaluation of immediately restored maxillary TiOblast single\u2010tooth implants","volume":"19","author":"Norton MR","year":"2004","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2012.00448.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00726.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01317.x"},{"key":"e_1_2_8_13_1","first-page":"179","article-title":"Facial gingival tissue stability following immediate placement and provisionalization of maxillary anterior single implants: a 2\u2010 to 8\u2010year follow\u2010up","volume":"26","author":"Kan JY","year":"2011","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100115"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-10-00110"},{"key":"e_1_2_8_16_1","first-page":"9","article-title":"Crestal ridge width changes when placing implants at the time of tooth extraction with and without soft tissue augmentation after a healing period of 6 months: report of 24 consecutive cases","volume":"31","author":"Grunder U","year":"2011","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2003.09.017"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.id.0000227078.70869.20"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01460.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1995.060108.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01020.x"},{"key":"e_1_2_8_22_1","first-page":"657","article-title":"Immediate implant placement and provisionalization with and without a connective tissue graft: an analysis of facial gingival tissue thickness","volume":"32","author":"Rungcharassaeng K","year":"2012","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.1849"},{"key":"e_1_2_8_24_1","first-page":"27","article-title":"Connective tissue grafts for thickening peri\u2010implant tissues at implant placement. One\u2010year results from an explanatory split\u2010mouth randomised controlled clinical trial","volume":"3","author":"Wiesner G","year":"2010","journal-title":"Eur J Oral Implantol"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_8_26_1","volume-title":"Cochrane Handbook for Systematic Reviews for Interventions Version 5.1.0","author":"Higgins JPT","year":"2011"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/ACPJC-1995-123-3-A12"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12132"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2018.07.003"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0061"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13258"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.3224"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12194"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3379"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12820"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025491"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01413.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb00837.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12045"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090385"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1815-2"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-2007-9"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150287"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150383"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13148"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12606"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7374129"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12220"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2014.10.001"}],"container-title":["Journal of Esthetic and Restorative Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jerd.12538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jerd.12538","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jerd.12538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T06:49:06Z","timestamp":1694069346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jerd.12538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,4]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/jerd.12538"],"URL":"https:\/\/doi.org\/10.1111\/jerd.12538","archive":["Portico"],"relation":{},"ISSN":["1496-4155","1708-8240"],"issn-type":[{"value":"1496-4155","type":"print"},{"value":"1708-8240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,4]]},"assertion":[{"value":"2019-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}