{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:09:36Z","timestamp":1790024976956,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002850","name":"FONDECYT","doi-asserted-by":"publisher","award":["1170575"],"award-info":[{"award-number":["1170575"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study assessed IL\u20101\u03b2 and RANK\u2010L levels in vivo and color stability of non\u2010vital teeth bleached using hydrogen (35%) and carbamide (37%) peroxides 3 months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fifty teeth were randomly divided into two groups(n = 25):35% hydrogen peroxide (HP) or 37% carbamide peroxide (CP). Four sessions of intracoronal walking\u2010bleach procedure were performed. IL\u20101\u03b2 and RANK\u2010L levels were assessed from gingival crevicular fluid samples (from three vestibular and three palatines sites) at eight different time\u2010points: at the beginning of the study (baseline), after four sessions of intracanal bleaching, and at 1\u2009week, 1\u2009month, and 3 months posttreatment. The color variations were visually detected using Vita bleach shade guide (\u0394SGU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant increases of IL\u20101\u03b2 and RANK\u2010L levels were detected at all time\u2010points (all <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) when comparing each time\u2010point to baseline, and a high correlation (&gt;0.8\u2014Spearman) between variables. According the \u0394SGU values, a color change of five for HP and four for CP were detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010vital walking bleach technique promotes an increase in IL\u20101\u03b2 and RANKL levels in periodontal tissues and also, it is maintained until the third\u2010month posttreatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>The internal whitening of teeth increases the levels of cytokines associated with inflammation and bone resorption 3 months after the whitening procedure is finished; this should warn of possible harmful effects of this whitening technique.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jerd.12557","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T02:09:15Z","timestamp":1577412555000},"page":"119-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Inflammatory markers IL\u20101\u03b2 and RANK\u2010L assessment after non\u2010vital bleaching: A 3\u2010month follow\u2010up"],"prefix":"10.1111","volume":"32","author":[{"given":"Cristian","family":"Bersezio","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, Faculty of Dentistry University of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Faculty of Dentistry University of Chile  Santiago 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