{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:23:27Z","timestamp":1792790607861,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this review is to address the potential applications of allogenous dermal matrix (ADM), as an alternative to subepithelial connective tissue graft (SCTG), in promoting periodontal phenotype modification (PPM) of challenging periodontal\u2010orthodontic clinical scenarios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Overview<\/jats:title><jats:p>The rationale behind the need of changing thin to thick gingival tissues is associated to the superior and more stable treatment outcomes promoted by PPM therapy. PPM, via soft tissue grafting, leads to clinical and histological changes of the pre\u2010established original genetic conditions of the gingiva. Although SCTG\u2010based procedures are recognized as the \u201cgold standard\u201d for the treatment of sites requiring root coverage and gingival augmentation, ADM has been recognized as the most suitable alternative to SCTG, particularly in clinical scenarios where the use of autogenous grafts is not possible. Thus, ADM is considered an optimal option for the treatment of patients with a history (or in need) of orthodontic tooth movement, due its two\u2010fold potential indication: (1) the promotion of periodontal soft tissue phenotype modification; and (2) its use, as a barrier membrane, in hard tissues augmentation procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ADM is a viable option for soft tissue augmentation, as well as for treatment approaches involving buccal bone gain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Periodontal phenotype modification therapy, when applied in challenging periodontal\u2010orthodontic clinical scenarios, promotes root coverage and prevents the onset and development clinical attachment loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jerd.12980","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T13:24:39Z","timestamp":1668777879000},"page":"158-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Periodontal phenotype modification of complexes periodontal\u2010orthodontic case scenarios: A clinical review on the applications of allogenous dermal matrix as an alternative to subepithelial connective tissue graft"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-1015","authenticated-orcid":false,"given":"Leandro","family":"Chambrone","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz, CRL  Monte de Caparica Portugal"},{"name":"Unit of Basic Oral Investigation (UIBO) School of Dentistry, Universidad El Bosque  Bogota Colombia"},{"name":"Department of 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