{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:05:57Z","timestamp":1781852757183,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005852","name":"Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005852","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to assess the feasibility of phenotype modification in orthodontic patients using combined bone and soft tissue grafting substitutes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Consideration<\/jats:title><jats:p>The surgical procedure was conducted on 18 patients (3 males, 15 females). Periodontal phenotype modification was conducted using demineralized freeze\u2010dried bone allograft and a xenogeneic collagen matrix. The following parameters were recorded for each tooth at baseline and 12\u2010month follow\u2010up: O'Leary plaque index (PI), probing depth (PD), bleeding on probing (BOP), gingival thickness (GT), keratinized tissue width (KTW), gingival recession (GR), and vestibular depth (VD). The results showed a statistically significant increase in GT (2.02\u2009\u00b1\u20090.39\u2009mm), KTW (1.11\u2009\u00b1\u20090.82\u2009mm), and VD (0.18\u2009\u00b1\u20091.16\u2009mm) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). GR was also significantly decreased (1.02\u2009\u00b1\u20090.99\u2009mm) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitation of this study, the proposed approach enhanced the periodontal condition in orthodontic patients. However, further studies with a larger sample size are needed to ensure long\u2010term stability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Hard and soft tissue conditions have paramount importance for long\u2010term periodontal stability. Phenotype modification in orthodontic patients can diminish the probability of adverse consequences and result in optimal esthetic outcomes. The proposed technique using combined bone and soft tissue substitutes indicated promising results and could be recommended in orthodontic patients with thin periodontal phenotypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jerd.13149","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T09:30:13Z","timestamp":1697621413000},"page":"548-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Periodontal phenotype modification in orthodontic patients"],"prefix":"10.1111","volume":"36","author":[{"given":"Mahdi","family":"Kadkhodazadeh","sequence":"first","affiliation":[{"name":"Dental Research Center, Research Institute for Dental Sciences, School of Dentistry Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Periodontics, School of Dentistry Shahid Beheshti University of Medical Sciences  Tehran 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