{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:34:31Z","timestamp":1790836471816,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study aimed to evaluate the effect of remineralizing agents on demineralized enamel intended for use as fluoride substitutes or supplements for oral hygiene applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Enamel samples were obtained from 30 bovine teeth. The enamel blocks were stored in 20\u2009mL of demineralization solution for 72\u2009h. They were then brushed with the following toothpaste for the remineralization protocol: NaF, NaF\/SnF\n                      <jats:sub>2<\/jats:sub>\n                      combination, NovaMin, or nano\u2010hydroxyapatite. SEM\/EDX examinations and microhardness measurements of the samples were performed to investigate the remineralization efficacy of the studied toothpaste. One\u2010way analysis of variance (ANOVA) with post hoc Tukey's HSD test was used to analyze the change in microhardness values in different remineralization protocols (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Differences in the mean remineralization (%RP) and hardness recovery (%HR) were determined between the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Groups 1 and 4 showed significant differences in %RP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In the SEM\/EDX examinations, the samples treated with n\u2010HAp showed an accumulation of crystal deposits on the enamel surface, although at a lower density than those treated with NaF and NaF\/SnF\n                      <jats:sub>2<\/jats:sub>\n                      combination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The remineralization strategy in toothpaste plays an important role in enamel remineralization. NovaMin\u2010containing toothpaste showed positive effects on the enamel surface with better Ca\/P ratio. Toothpastes containing n\u2010HAp triggered less change in the increase of microhardness values compared to other toothpastes. The use of SnF\n                      <jats:sub>2<\/jats:sub>\n                      in toothpaste in combination with NaF significantly increased the binding of fluoride to demineralized enamel compared to toothpaste containing NaF alone.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jerd.13150","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T06:36:18Z","timestamp":1697524578000},"page":"663-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ultrastructural investigation of the effect of toothpastes containing different remineralizing agents on demineralized enamel"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-1763","authenticated-orcid":false,"given":"Burak","family":"G\u00fcm\u00fc\u015fta\u015f","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry Istanbul 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