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A systematic literature review was conducted across five databases to gather evidence. The recommendations, informed by findings from systematic reviews and formulated based on a two\u2010phase e\u2010Delphi survey, emphasize a comprehensive treatment strategy that includes noninvasive measures alongside restorative interventions for managing dental caries and tooth wear. The recommendations advocate for selecting between direct and indirect restorations on a case\u2010by\u2010case basis, favoring inlays and onlays over crowns to align with minimally invasive dentistry principles. The recommendations highlight the critical role of selecting restorative biomaterials based on clinical performance, esthetic properties, and adherence to manufacturer guidelines. They emphasize the importance of precision in restorative procedures, including tooth preparation, impression taking, contamination control, and luting. Regular follow\u2010up and maintenance tailored to individual patient needs are crucial for the longevity of ceramic and nonmetallic restorations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These PROSEC recommendations provide a framework for dental practitioners to deliver high\u2010quality restorative care, advocating for personalized treatment planning and minimally invasive approaches to optimize oral health outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>The PROSEC North America recommendations highlight the importance of minimally invasive techniques in posterior tooth restorations using ceramic and non\u2010metallic biomaterials. These principles prioritize tooth structure conservation and personalized treatment planning, essential for enhancing clinical outcomes and long\u2010term oral health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jerd.13289","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T10:21:13Z","timestamp":1722594073000},"page":"809-820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interdisciplinary <scp>Delphi<\/scp> study by <scp>PROSEC<\/scp> North America: Recommendations on single indirect restorations made from ceramic and nonmetallic biomaterials for posterior teeth"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6185-1480","authenticated-orcid":false,"given":"Florin","family":"Eggmann","sequence":"first","affiliation":[{"name":"Department of Preventive and Restorative Sciences, Robert Schattner Center, Penn Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Periodontology, Endodontology, and Cariology University Center for Dental Medicine Basel UZB, University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia L.","family":"Orta","sequence":"additional","affiliation":[{"name":"Department of Advanced Oral Sciences and Therapeutics, Division of Prosthodontics University of Maryland School of Dentistry, University of Maryland  Baltimore Maryland USA"},{"name":"Department of Restorative Sciences, Advanced Education in Prosthodontics The Dental College of Georgia at Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awab","family":"Abdulmajeed","sequence":"additional","affiliation":[{"name":"Department of General Practice and Prosthodontics, School of Dentistry Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Att","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry, Center for Dental Medicine Medical Center\u2010University of Freiburg, Faculty of Medicine, University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Beuer","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bergler","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Sciences, Robert Schattner Center, Penn Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-7047","authenticated-orcid":false,"given":"Markus B.","family":"Blatz","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Sciences, Robert Schattner Center, Penn Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Brief","sequence":"additional","affiliation":[{"name":"PROSEC gGmbH  Bad S\u00e4ckingen Germany"},{"name":"VITA Zahnfabrik  Bad S\u00e4ckingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor E.","family":"Castro","sequence":"additional","affiliation":[{"name":"Studio\u2010280  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6577-781X","authenticated-orcid":false,"given":"Lyndon F.","family":"Cooper","sequence":"additional","affiliation":[{"name":"School of Dentistry Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Han","sequence":"additional","affiliation":[{"name":"Master's Arch  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry University of Illinois College of Dentistry  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8459-5528","authenticated-orcid":false,"given":"Rade D.","family":"Paravina","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Prosthodontics, John M. 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