{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:31:55Z","timestamp":1789601515239,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess the remineralization efficacy of casein phosphopeptide\u2010amorphous calcium phosphate (CPP\u2010ACP), silver diamine fluoride\/potassium iodide (SDF\/KI), and sodium fluoride with functionalized tricalcium phosphate (NaF\/fTCP) on artificial early enamel lesion using laser fluorescence and micro\u2010CT analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      On extracted impacted third molars, artificial enamel lesions were prepared. Twenty\u2010eight specimens were randomly assigned to four groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097 per group): a control group (artificial saliva), CPP\u2010ACP (GC Tooth Mousse), SDF\/KI (Riva Star), and NaF\/fTCP (Clinpro White varnish). Following the manufacturer's instructions, the remineralization agents were applied to demineralized surfaces. Laser fluorescence and micro\u2010CT were used to evaluate the remineralization efficacy of the agents and analyzes were performed during four stages: before demineralization, after demineralization, 1st day of remineralization and 30th day of remineralization. Shapiro\u2013Wilk test, repeated measures two\u2010way ANOVA, and Spearman correlation tests were used for statistical analysis. A significant level of\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 was established.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SDF\/KI significantly reduced the lesion area and lesion volume on the demineralized enamel surface after 30\u2009days of remineralization. In the T3 period, SDF\/KI increased the mineral density statistically significantly compared to the T1 period. The laser fluorescence values for all three remineralizing agents exhibited a linear decrease. A significant correlation between the fluorescence values and the mineral density was found (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>All three investigated agents were showed positive remineralization efficacy on artificial enamel lesion. However, SDF\/KI, containing silver diamine fluoride and potassium iodide exhibited superior than other agents in promoting remineralization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Although all three remineralization agents showed positive remineralization efficacy on artificial enamel lesions, SDF had higher remineralization performance over the other two agents. SDF has potential to prevent progression of demineralization in treating children with high caries risk in the long\u2010term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jerd.13292","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T11:43:51Z","timestamp":1722426231000},"page":"1536-1546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Remineralization efficiency of three different agents on artificially produced enamel lesions: A micro\u2010\n                    <scp>CT<\/scp>\n                    study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3679-4001","authenticated-orcid":false,"given":"Sabiha Ceren","family":"\u0130lisulu","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry Alt\u0131nba\u015f University  Istanbul 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