{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:46:00Z","timestamp":1787751960964,"version":"build-2784847793"},"reference-count":72,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T00:00:00Z","timestamp":1738454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the presence of nano\u2010encapsulated flavonoids and their effect in universal adhesives on resin\u2010dentin bond\u2010strength (\u03bcTBS) and nanoleakage (NL) on artificial caries\u2010affected dentin (CAD) after 24\u2010h and 6 months of water storage (WS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Artificial CAD was created on the occlusal dentin surfaces of 60 human third molars by a microbiological assay. Nanoencapsulated quercetin (Q) and naringin (N) were incorporated into Prime&amp;Bond Universal (PBU; Dentsply\u2010Sirona) and Single Bond Universal (SBU, 3M ESPE). The adhesive systems with and without (control) flavonoids were applied to the CAD surface, and a 4\u2010mm resin composite block (TPH Spectrum, Dentsply Sirona) was built up and light\u2010cured. Specimens were sectioned into resin\u2010dentin beams (0.8\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      ). The hybrid layer (HL) was subjected to micro\u2010Raman analysis to detect N and Q. The specimens were tested in tension in a universal testing machine at 0.5\u2009mm\/min. \u03bcTBS and NL tests were performed after 24\u2010h and WS. \u03bcTBS and NL data were analyzed using a nonparametric three\u2010way ANOVA test followed by Bonferroni's test (\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20095%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Q and N were detected within the HL. N and Q nanocapsules increased \u03bcTBS and reduced NL values after WS. At 24\u2009h, the PBU group showed higher NL values than the SBU group, and the values decreased after WS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Incorporating nanoencapsulated flavonoids may improve the longevity of universal bonding systems applied to CAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Adhesive restorations incorporating nanoencapsulated quercetin or naringin might be a promising alternative for achieving long\u2010term bonding stability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jerd.13426","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:38:11Z","timestamp":1738543091000},"page":"1546-1556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["How Universal Adhesive Systems With Nanoencapsulated Flavonoids Improve Long\u2010Term Bonding to Caries\u2010Affected Dentin"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-4058","authenticated-orcid":false,"given":"Camila","family":"Falconi\u2010P\u00e1ez","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry State University of Ponta Grossa, Av. General Carlos Cavalcanti  Ponta Grossa Parana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra Alejandra Nu\u00f1ez","family":"Aldaz","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry State University of Ponta Grossa, Av. General Carlos Cavalcanti  Ponta Grossa Parana Brazil"},{"name":"Department of Restorative Dentistry and Dental Materials School of Dentistry, Universidad San Francisco de Quito USFQ  Quito Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobia Gast\u00f3n","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry State University of Ponta Grossa, Av. General Carlos Cavalcanti  Ponta Grossa Parana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Carolina","family":"Gonz\u00e1lez\u2010Vaca","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Dental Materials School of Dentistry, Universidad San Francisco de Quito USFQ  Quito Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Arrais","family":"Campos","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University  Tampere Finland"},{"name":"School of Dentistry, Campus Araraquara, S\u00e3o Paulo State University (UNESP)  S\u00e3o Paulo Brazil"},{"name":"Institute of Dentistry, Faculty of Health Sciences, University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Davila\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Dental Materials School of Dentistry, Universidad San Francisco de Quito USFQ  Quito Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Augusto Galv\u00e3o","family":"Arrais","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry State University of Ponta Grossa, Av. 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