{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:06:55Z","timestamp":1788786415135,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the long\u2010term microtensile bond strength (\u03bcTBS) to coronal dentin using pre\u2010endodontic dentin sealing (PEDS) and post\u2010endodontic adhesion (PEA) techniques under various endodontic irrigation protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Ten study groups (<jats:italic>n<\/jats:italic>\u2009=\u200910) were established based on the timing of adhesive application (PEDS versus PEA) and irrigation protocol: distilled water (control), 3% sodium hypochlorite (NaOCl), 3% NaOCl followed by 17% ethylenediaminetetraacetic acid (EDTA), 3% NaOCl followed by 17% EDTA and 2% chlorhexidine, and a mixture of 3% NaOCl and 9% etidronic acid (HEDP). Specimens underwent \u03bcTBS testing after a six\u2010month microspecimen aging period. Fracture patterns were analyzed, and adhesive interfaces were assessed using scanning electron microscopy (SEM). Statistical analysis employed a mixed linear regression model with a 5% significance level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PEDS consistently preserved high bond strength across all irrigation protocols (57.4\u201359.5\u2009MPa), while PEA groups treated with endodontic irrigants resulted in significantly lower values (33.3\u201340.8\u2009MPa; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). No significant differences were observed within the PEDS groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). SEM analysis revealed consistent hybrid layers in PEDS and PEA\/Control groups, while PEA groups treated with endodontic irrigation solutions showed significant resin\u2013dentin interface variations and interfacial gaps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The PEDS technique preserved high and consistent \u03bcTBS regardless of the irrigation protocol, whereas endodontically irrigated PEA groups exhibited significantly reduced bond strength. PEDS offers a predictable approach to optimizing adhesive performance in endodontic\u2010restorative treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Integrating PEDS into routine endodontic\u2010restorative workflow is recommended to enhance long\u2010term bond strength to coronal dentin. The PEDS technique ensures consistent adhesive performance regardless of the endodontic irrigation protocol, enhancing restorative predictability and treatment success while preserving tooth structure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jerd.13467","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T19:35:56Z","timestamp":1744918556000},"page":"1865-1881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Advancing Adhesive Strategies for Endodontically Treated Teeth\u2014Part <scp>II<\/scp>: Dentin Sealing Before Irrigation Increases Long\u2010Term Microtensile Bond Strength to Coronal Dentin"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-6155","authenticated-orcid":false,"given":"Joana A.","family":"Marques","sequence":"first","affiliation":[{"name":"Institute of Endodontics, Faculty of Medicine University of Coimbra  Coimbra Portugal"},{"name":"Center for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7099-8871","authenticated-orcid":false,"given":"Rui I.","family":"Falacho","sequence":"additional","affiliation":[{"name":"Center for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine University of Coimbra  Coimbra Portugal"},{"name":"Department of Preventive and Restorative Sciences University of Pennsylvania School of Dental Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6170-4857","authenticated-orcid":false,"given":"Gabriela","family":"Almeida","sequence":"additional","affiliation":[{"name":"Dentistry Department, Faculty of Medicine University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0015-8604","authenticated-orcid":false,"given":"Francisco","family":"Caramelo","sequence":"additional","affiliation":[{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB) University of Coimbra  Coimbra Portugal"},{"name":"Laboratory of Biostatistics and Medical Informatics, Faculty of Medicine University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2865-9689","authenticated-orcid":false,"given":"Jo\u00e3o Miguel","family":"Santos","sequence":"additional","affiliation":[{"name":"Institute of Endodontics, Faculty of Medicine University of Coimbra  Coimbra Portugal"},{"name":"Center for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine University of Coimbra  Coimbra Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR) and Center of Investigation on Environment Genetics and Oncobiology (CIMAGO) Faculty of Medicine and Clinical Academic Center of Coimbra (CACC)  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0417-9402","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Chemistry CICECO \u2010 Aveiro Institute of Materials, University of Aveiro  Aveiro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-7047","authenticated-orcid":false,"given":"Markus B.","family":"Blatz","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Sciences University of Pennsylvania School of Dental Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-1092","authenticated-orcid":false,"given":"Jo\u00e3o Carlos","family":"Ramos","sequence":"additional","affiliation":[{"name":"Center for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine University of Coimbra  Coimbra Portugal"},{"name":"Institute of Operative Dentistry, Faculty of Medicine University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4730-8072","authenticated-orcid":false,"given":"Paulo J.","family":"Palma","sequence":"additional","affiliation":[{"name":"Institute of Endodontics, Faculty of Medicine University of Coimbra  Coimbra Portugal"},{"name":"Center for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2008.01540.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13739"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.13135"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2005.09.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57009-x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.don.0000158233.59316.fe"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12329"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12424"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2009.12.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.08.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01872.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1995.tb00150.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2002.00546.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13796"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.10.023"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2020.08.004"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.05.002"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2022.11.007"},{"issue":"1","key":"e_1_2_9_20_1","first-page":"7","article-title":"From Buonocore's Pioneering Acid\u2010Etch Technique to Self\u2010Adhering Restoratives. A Status Perspective of Rapidly Advancing Dental Adhesive Technology","volume":"22","author":"Van Meerbeek B.","year":"2020","journal-title":"Journal of Adhesive Dentistry"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.13460"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1930360"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.07.001"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200405000-00013"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697412"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJB11.164"},{"issue":"3","key":"e_1_2_9_27_1","first-page":"105","article-title":"Bond Strength to Deep Coronal Dentin: Effect of Bonding Strategies","volume":"56","author":"Giovannone T.","year":"2007","journal-title":"Minerva Stomatologica"},{"issue":"2","key":"e_1_2_9_28_1","first-page":"e127","article-title":"Shear Bond Strength of One\u2010Step Self\u2010Etch Adhesives to Dentin: Evaluation of NaOCl Pretreatment","volume":"10","author":"Colombo M.","year":"2018","journal-title":"Journal of Clinical and Experimental Dentistry"},{"issue":"2","key":"e_1_2_9_29_1","first-page":"82","article-title":"The Effect of Titanium Tetrafluoride and Sodium Hypochlorite on the Shear Bond Strength of Methacrylate and Silorane Based Composite Resins: An in\u2010VitroStudy","volume":"18","author":"Sharafeddin F.","year":"2017","journal-title":"Journal of Dentistry"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1980-65232011000400012"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2005.01.008"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.5395\/rde.2020.45.e44"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.5301\/jabfm.5000240"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4477.2010.00249.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3400539"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800101101"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690100501"},{"issue":"4","key":"e_1_2_9_38_1","first-page":"177","article-title":"Bond Strengths to Endodontically\u2010Treated Teeth","volume":"12","author":"Nikaido T.","year":"1999","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.5395\/rde.2018.43.e14"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2009.11.006"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCD.JCD_502_18"},{"issue":"1","key":"e_1_2_9_42_1","first-page":"13","article-title":"Dentin Permeability: Sealing the Dentin in Crown Preparations","volume":"17","author":"Pashley E. L.","year":"1992","journal-title":"Operative Dentistry"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8240.2005.tb00103.x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2016.04.001"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2021.05.004"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.01.001"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2012.01.004"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2013.08.001"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12938"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijadhadh.2019.102419"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-014-0174-1"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.13395"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.936"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma17051015"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2016.11.015"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0109-5641(95)80046-8"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.12289"},{"issue":"2","key":"e_1_2_9_58_1","first-page":"167","article-title":"Immediate and Delayed Bond Strength of a Multimode Adhesive to Deep Coronal Dentin Following Different Root Canal Irrigation Regimens","volume":"23","author":"Spicciarelli V.","year":"2021","journal-title":"Journal of Adhesive Dentistry"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572010000400011"},{"issue":"1","key":"e_1_2_9_60_1","first-page":"63","article-title":"Bonding Strategies to Pulp Chamber Dentin Treated With Different Endodontic Irrigants: Microshear Bond Strength Testing and SEM Analysis","volume":"12","author":"Fawzi E. M.","year":"2010","journal-title":"Journal of Adhesive Dentistry"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2007.02.009"},{"issue":"2","key":"e_1_2_9_62_1","first-page":"142","article-title":"Effect of Calcium Removal on Dentin Bond Strengths","volume":"32","author":"Perdig\u00e3o J.","year":"2001","journal-title":"Quintessence International"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.13183"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/150251"},{"issue":"6","key":"e_1_2_9_65_1","first-page":"499","article-title":"Effect of Different Antioxidants on the Microtensile Bond Strength of an Adhesive System to Sodium Hypochlorite\u2010Treated Dentin","volume":"17","author":"Dikmen B.","year":"2015","journal-title":"Journal of Adhesive Dentistry"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.11.010"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2015.11.007"}],"container-title":["Journal of Esthetic and Restorative Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jerd.13467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T08:48:52Z","timestamp":1749718132000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jerd.13467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":66,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jerd.13467"],"URL":"https:\/\/doi.org\/10.1111\/jerd.13467","archive":["Portico"],"relation":{},"ISSN":["1496-4155","1708-8240"],"issn-type":[{"value":"1496-4155","type":"print"},{"value":"1708-8240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"assertion":[{"value":"2025-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}