{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:22Z","timestamp":1791945922154,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304444\/2025\u20101"],"award-info":[{"award-number":["304444\/2025\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This randomized, parallel, double\u2010blind clinical trial aimed to evaluate the equivalence in bleaching efficacy (BE), as well as the risk and intensity of tooth sensitivity (TS), in participants undergoing in\u2010office dental bleaching with low (6%) versus high\u2010concentration (35%) hydrogen peroxide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      A total of 140 participants were randomly assigned to one of the two groups according to the bleaching gel concentration used: 6% hydrogen peroxide (Automixx 6%, FGM) or 35% hydrogen peroxide (Automixx Plus 35%, FGM), the bleaching procedure was performed for 50\u2009min in three sessions, with 1\u2010week interval. The bleaching procedure was performed for 50\u2009min in three sessions, with a 1\u2010week interval. BE was evaluated using a Vita Easyshade spectrophotometer (\u0394E\n                      <jats:sub>00<\/jats:sub>\n                      , \u0394E\n                      <jats:sub>ab<\/jats:sub>\n                      , and \u0394WI\n                      <jats:sub>D<\/jats:sub>\n                      ) and both Vita Classical and Vita Bleachedguide shade guides (\u0394SGU) at days 7, 14, and 21, and 1 month after completion treatment. The risk and intensity of TS were recorded using a visual analog scale (VAS; 0 to 10), assessed immediately after each of the three bleaching sessions, and at 1, 24, and 48\u2009h posttreatment. BE was assessed with a paired Student's\n                      <jats:italic>t<\/jats:italic>\n                      test. The absolute risk of TS was evaluated using the Fisher's exact test, and the TS intensity was assessed using a paired Student's\n                      <jats:italic>t<\/jats:italic>\n                      test (\u03b1\u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nonequivalent bleaching outcomes were observed between the groups across all instruments and time points (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The 35% hydrogen peroxide group showed significantly greater efficacy than the 6% group (MD in \u0394E\n                      <jats:sub>00<\/jats:sub>\n                      \u2009=\u20096.3; 90% CI 4.8\u20137.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The risk of TS was lower in the 6% group (44%) compared with the 35% group (74%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0005). Sensitivity intensity was also significantly lower in the 6% group up to 24\u2009h posttreatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In\u2010office dental bleaching with 6% and 35% hydrogen peroxide resulted in significant tooth whitening; however, the outcomes were not equivalent across all evaluation time points, with the 35% concentration demonstrating superior efficacy throughout the study. In contrast, TS was significantly higher in the 35% group compared with the 6% group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>While 35% hydrogen peroxide delivers more effective tooth whitening in\u2010office, it is also associated with a higher risk and intensity of TS. Lower concentrations like 6% offer a safer alternative with reduced sensitivity but less whitening efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jerd.70090","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T18:27:11Z","timestamp":1767032831000},"page":"905-914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Tooth Sensitivity of Low\u2010 Versus High\u2010Concentration Hydrogen Peroxide for In\u2010Office Bleaching: A Randomized Clinical Trial"],"prefix":"10.1111","volume":"38","author":[{"given":"Gabrielle Gomes","family":"Centenaro","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry State University of Ponta Grossa  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-7915","authenticated-orcid":false,"given":"Michael Willian","family":"Favoreto","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry Tuiuti University of Paran\u00e1  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5796-014X","authenticated-orcid":false,"given":"Taynara de Souza","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry State University of Ponta Grossa  Paran\u00e1 Brazil"},{"name":"Area of Stomatology, IDIBO Research Group, Health Sciences Faculty Rey Juan Carlos University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4024-4037","authenticated-orcid":false,"given":"Deisy Cristina Ferreira","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry State University of Ponta Grossa  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9880-4856","authenticated-orcid":false,"given":"Alessandro D.","family":"Loguercio","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry State University of Ponta Grossa  Paran\u00e1 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