{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:23:55Z","timestamp":1791332635524,"version":"4.3.1"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systematic review and network meta\u2010analysis aimed to compare and rank the clinical performance of ormocer\u2010based resin composites versus conventional resin\u2010based composites in posterior Class I and II restorations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Electronic searches were conducted in PubMed, Web of Science, Cochrane Library, Embase, and Scopus up to October 2025. Randomized controlled and prospective clinical trials evaluating ormocer\u2010based versus conventional resin composites with at least 6\u2010month follow\u2010ups were included. Primary outcomes were marginal adaptation, retention, and fracture, assessed using USPHS or FDI criteria. A random\u2010effects NMA was performed using the netmeta package (R), calculating risk ratios and P\u2010scores across 6\u2010, 12\u2010, 24\u2010, and 36\u2010month intervals. Risk of bias was assessed with RoB 2, and certainty of evidence through CINeMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve trials (2006\u20132024; 1158 restorations) met eligibility. Across all time points, ormocer\u2010based materials including hybrid and bulk\u2010fill variants showed no statistically significant differences versus conventional methacrylate composites for marginal adaptation, retention, or fracture (RR\u2009=\u20091.0 with 95% CIs spanning unity). Treatment rankings based on\n                      <jats:italic>p<\/jats:italic>\n                      \u2010scores were closely clustered (\u22480.3\u20130.6), indicating probabilistic equivalence. Most studies showed a low overall risk of bias; the CINeMA appraisal supported moderate confidence in the main contrasts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Across 6\u201336\u2009months, ormocer\u2010based composites (including hybrid and bulk\u2010fill formulations) showed no statistically significant differences versus conventional methacrylate\u2010based composites for marginal adaptation, retention, or fracture, and treatment rankings were closely clustered, indicating probabilistic equivalence rather than superiority. The certainty of evidence was overall moderate, primarily limited by imprecision and reduced network density at longer follow\u2010ups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Bis\u2010GMA\u2010free ormocer formulations may help reduce exposure to BPA\u2010related eluates without compromising clinical performance, although longer follow\u2010up is warranted.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      PROSPERO; registration number\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420251172319\">CRD420251172319<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jerd.70120","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:23:33Z","timestamp":1770290613000},"page":"1338-1352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Performance of Ormocer\u2010Based Versus Conventional Methacrylate\u2010Based Resin Composites in Posterior Restorations: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8571-4429","authenticated-orcid":false,"given":"Alain Manuel","family":"Chaple Gil","sequence":"first","affiliation":[{"name":"Universidad Aut\u00f3noma de Chile. Facultad de Ciencias de la Salud  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-6931","authenticated-orcid":false,"given":"Laura","family":"Pereda V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Penn Dental Medicine University of Pennsylvania  Philadelphia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5935-9313","authenticated-orcid":false,"given":"Meylin","family":"Santiesteban Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Universidad de Ciencias M\u00e9dicas de La Habana  La Habana Cuba"},{"name":"Universidad Aut\u00f3noma del Paraguay  Asunci\u00f3n Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7249-0541","authenticated-orcid":false,"given":"Jorge J.","family":"Menendez","sequence":"additional","affiliation":[{"name":"Nova Southeastern University\u2014College of Dental Medicine  Fort Lauderdale USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2021.12.010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2018.03.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2019.11.016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2018.1556853"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2015.11.020"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adv.21564"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pc.29748"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adv.21503"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.48576"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pc.26401"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43246\u2010025\u201000826\u2010y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmae025"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010019\u201002912\u20101"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010018\u20102651\u20103"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/separations10080455"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2024.127731"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/m14\u20102385"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1566-9_12"},{"key":"e_1_2_9_21_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions. 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