{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:12:06Z","timestamp":1779354726308,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n This study aimed to evaluate the effect of different bulk\u2010fill base materials and inlay fabrication techniques on the fracture resistance of structurally compromised premolars.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n Sixty intact premolars were randomly allocated to five groups (\n n<\/jats:italic>\n \u2009=\u200912). Standardized slot\u2010type mesio\u2010occluso\u2010distal cavities with undermined cusps were prepared in all groups except the intact control group. Teeth were restored with different base materials: flowable bulk\u2010fill composite resin (BF\u2010RBC) or short fiber\u2010reinforced composite (SFRC) resin. Each group was further subdivided according to the fabrication technique of the CAD\/CAM inlays (milled hybrid nano\u2010ceramic composite or 3D\u2010printed ceramic\u2010filled hybrid composite resin). Fracture resistance was evaluated after thermocycling aging for 10,000\u2009cycles, and the failure mode was inspected. Data were analyzed using heteroscedasticity\u2010corrected two\u2010way ANOVA with post hoc pairwise comparisons of the significant main effect (\n \u03b1<\/jats:italic>\n \u2009=\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fracture resistance was significantly influenced by inlay fabrication technique (\n p<\/jats:italic>\n \u2009<\u20090.001) but not by base material or their interaction. In milled groups, SFRC exhibited a statistically more favorable failure mode than BF\u2010RBC, whereas no significant differences were observed in 3D\u2010printed groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n CAD\/CAM\u2010milled restorations demonstrated superior fracture resistance compared with 3D\u2010printed restorations in structurally compromised premolars.<\/jats:p>\n <\/jats:sec>\n \n Clinical Significance<\/jats:title>\n Selecting restorative materials with appropriate compliance is essential to accommodate tooth flexure and minimize fracture risk. CAD\/CAM composite restorations provide a conservative approach for restoring structurally compromised premolars, and base material selection should be considered to enhance the stress distribution of the overlying inlay and support overall restoration longevity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jerd.70128","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T08:42:57Z","timestamp":1771404177000},"page":"1250-1258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Covering Different Base Materials With\n CAD<\/scp>\n \/\n CAM<\/scp>\n \u2010Milled and\n 3D<\/scp>\n \u2010Printed Inlays on the Fracture Resistance of Structurally Compromised Premolars"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0487-353X","authenticated-orcid":false,"given":"Rolla","family":"Adel","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry, Faculty of Dentistry Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahla","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, Faculty of Dentistry Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Amr","family":"Kamel","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, Faculty of Dentistry Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zainab","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, Faculty of Dentistry Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/endo.endo_94_24"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10015-1637"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2020.01.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2025.09.034"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2020.11.026"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.12998"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2019.07.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2025.06.010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13132040"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym17111553"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2021.10.018"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05164-2"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.13473"},{"key":"e_1_2_10_15_1","article-title":"Fracture 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P.","year":"2023","journal-title":"Journal of Adhesive 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