{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:05:39Z","timestamp":1784300739841,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Virtual patient construction integrates dental, facial, and skeletal datasets into a unified 3D model for prosthodontic diagnosis and planning. Despite advances, fully digital workflows remain limited by challenges in reproducibility and clinical validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe an alternative digital workflow for 3D virtual patient construction integrating intraoral, facial, and CBCT data, and to demonstrate its clinical applicability through direct intraoral mock\u2010up validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A patient with esthetic concerns and mild functional asymmetry was documented using full\u2010arch intraoral scans, facial scans, and CBCT. Craniofacial reference planes guided multimodal alignment using an Iterative Closest Point (ICP) algorithm with predefined parameters. The integrated datasets were analyzed in a virtual articulator to simulate mandibular movements. A 3D\u2010printed model and silicone index enabled intraoral mock\u2010up validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The workflow achieved consistent multimodal alignment of hard\u2010 and soft\u2010tissue structures, eliminating the need for analog facebow transfer or mechanical mounting. The intraoral mock\u2010up reproduced the virtual design, confirming the clinical transferability of esthetic and functional parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This workflow integrates virtual planning with clinical validation, thereby improving diagnostic precision, esthetic predictability, and interdisciplinary communication in prosthodontic rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>This approach provides a reproducible option for virtual patient construction, enabling immediate chairside validation and supporting more predictable clinical decision\u2010making in esthetic and occlusal rehabilitation.<\/jats:p>\n                  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