{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:57:52Z","timestamp":1788267472242,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To synthesize umbrella\u2010level evidence on laser or light activation and photobiomodulation in in\u2010office dental bleaching, including whitening efficacy, tooth sensitivity, and biological safety. Systematic reviews were searched in PubMed, Embase, Scopus, Web of Science, and the Cochrane Library using terms related to dental bleaching, hydrogen peroxide, laser activation, light activation, and photobiomodulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Systematic reviews and meta\u2010analyses evaluating in\u2010office bleaching with optical activation or photobiomodulation were included. Outcomes were color change, tooth sensitivity, pulpal safety, and adverse effects. Methodological quality was assessed using A Measurement Tool to Assess Systematic Reviews 2, and certainty was judged through an umbrella\u2010level certainty framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten systematic reviews published from 2007 to 2024 were included. Laser or light activation showed no consistent improvement in final whitening efficacy compared with nonactivated protocols. Sensitivity was not reduced and was less favorable in some high\u2010energy protocols. Photobiomodulation reduced post\u2010bleaching sensitivity across placebo\u2010controlled randomized trials without impairing color change. Safety findings were mainly parameter\u2010dependent, especially regarding intrapulpal temperature during high\u2010energy activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Laser or light activation did not improve final whitening efficacy. Photobiomodulation reduced post\u2010bleaching sensitivity without reducing whitening efficacy. High\u2010energy activation showed parameter\u2010dependent thermal concerns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Current evidence does not support the routine use of laser activation to improve bleaching outcomes, whereas photobiomodulation represents a sensitivity\u2010reducing adjunct for susceptible patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jerd.70176","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:28:56Z","timestamp":1777876136000},"page":"1665-1690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Do Laser and Light Activation Improve In\u2010Office Dental Bleaching Outcomes? An Umbrella Review of Efficacy, Tooth Sensitivity, and Biological Safety"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2369-2882","authenticated-orcid":false,"given":"Javier Basualdo","family":"Allende","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Dental School University of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Campos\u2010Bijit","sequence":"additional","affiliation":[{"name":"Laboratory of Nanobiomaterials, Research Institute of Dental Sciences, Faculty of Dentistry, Universidad de Chile and N\u00facleo Milenio Bioproductos Gen\u00f3mica y Microbiolog\u00eda Ambiental (BioGEM)  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Morales\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Departament of Pathology and Oral Medicine, Faculty of Dentistry University of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4261-2000","authenticated-orcid":false,"given":"Leonardo","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Faculty of Dentistry Universidad de Sevilla  Sevilla Spain"},{"name":"Perioplastic Institute  Santiago Chile"},{"name":"Prosthetics Departament, Faculty of Dentistry University of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria C.","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Facultad de Odontologia Universidad de Chile  Santiago Chile"},{"name":"Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo  Ciudad Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-4648","authenticated-orcid":false,"given":"Eduardo","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Facultad de Odontologia Universidad de Chile  Santiago Chile"},{"name":"Instituto de Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.12152"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2341\/24-078-LIT"},{"issue":"10","key":"e_1_2_9_4_1","first-page":"881","article-title":"Tooth Sensitivity During and After Vital Tooth Bleaching: A Systematic Review on an Unsolved Problem","volume":"46","author":"Kielbassa A. 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