{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:02:59Z","timestamp":1789588979808,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the antioxidant capacity of the baicalein solution (BA), as well as its effect when applied for different times to the surface of bleached dental enamel, considering immediate color stability and bond strength.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Bovine enamel\/dentin specimens (4\u2009\u00d7\u20094\u2009\u00d7\u20093\u2009mm) were randomly divided into five groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910): Positive Control (PC): non\u2010bleached, restored teeth; Negative Control (NC): bleached, restored teeth; and BA5, BA10, BA15 groups, with BA applied for 5, 10, or 15\u2009min after bleaching with HP35%, followed by immediate restoration with Filtek Z350XT composite resin. The antioxidant activity (AA%) was evaluated using the DPPH test. Immediate color stability was assessed by \u0394E\n                      <jats:sub>00<\/jats:sub>\n                      and \u0394WID at T1 (post\u2010bleaching) and T2 (post\u2010BA application), with repeated measurements at 24\u2009h (T3) and 7\u2009days (T4). Micro\u2010shear bond strength (SBS) was evaluated at 24\u2009h and 7\u2009days. Statistical analysis was performed at a 5% significance level. SBS data were analyzed using two\u2010way ANOVA, \u0394E\n                      <jats:sub>00<\/jats:sub>\n                      with generalized linear models, and \u0394WID with Kruskal\u2013Wallis followed by Dunn's post hoc test. Antioxidant activity and failure modes were analyzed descriptively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The BA solution demonstrated an AA% of 97%. The final analyses (T4) of \u0394E\n                      <jats:sub>00<\/jats:sub>\n                      revealed that BA10 and BA15 presented statistically similar values to NC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.5), while BA5 exhibited the lowest \u0394E\n                      <jats:sub>00<\/jats:sub>\n                      among the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). For \u0394WID (T4), all groups showed values similar to NC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The application of BA improved SBS values at all time points (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), with adhesive failures being predominant, followed by mixed failures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Baicalein increased bond strength without compromising bleaching outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>The use of BA showed promising results, indicating its potential as a novel agent to be further studied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jerd.70239","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T06:36:11Z","timestamp":1786084571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of Baicalein Solution as a Novel Antioxidant After Bleaching: Analysis of Its Effects on Immediate Color Stability and the Reestablishment of Bond Strength in Bleached Enamel"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7963-1811","authenticated-orcid":false,"given":"Herica Myllena Correia","family":"da Silva","sequence":"first","affiliation":[{"name":"Piracicaba Dental School, Department of Restorative Dentistry State University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2520-0485","authenticated-orcid":false,"given":"Weslley Felipe","family":"Pin","sequence":"additional","affiliation":[{"name":"Piracicaba Dental School, Department of Restorative Dentistry State University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3608-2389","authenticated-orcid":false,"given":"Marina Rodrigues","family":"Santi","sequence":"additional","affiliation":[{"name":"Piracicaba Dental School, Department of Restorative Dentistry State University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5129-5599","authenticated-orcid":false,"given":"Beatriz Ometto","family":"Sahadi","sequence":"additional","affiliation":[{"name":"Piracicaba Dental School, Department of Restorative Dentistry State University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Roberto Marcondes","family":"Martins","sequence":"additional","affiliation":[{"name":"Piracicaba Dental School, Department of Restorative Dentistry State University of Campinas  Piracicaba S\u00e3o Paulo 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