{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:53:08Z","timestamp":1791381188626,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304444\/2025\u20101"],"award-info":[{"award-number":["304444\/2025\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Esthet Restor Dent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This randomized clinical trial evaluated the bleaching efficacy (BE), absolute risk and intensity of tooth sensitivity (TS), gingival irritation (GI), and esthetic self\u2010perception (ES) of an in\u2010office bleaching gel with an attachable syringe using different application tips in a randomized, double\u2010blind (participant\u2010 and evaluator\u2010blinded) clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010five participants received hemi\u2010arch bleaching using an attached brush and a conventional tip, performed in two sessions with hydrogen peroxide 35%. BE was evaluated at baseline, weekly, and 1\u2010month post\u2010bleaching using a spectrophotometer (\u0394\n                      <jats:italic>E<\/jats:italic>\n                      <jats:sub>ab<\/jats:sub>\n                      , \u0394\n                      <jats:italic>E<\/jats:italic>\n                      <jats:sub>00<\/jats:sub>\n                      , and \u0394WI\n                      <jats:sub>D<\/jats:sub>\n                      ) and shade guide units (\u0394SGU). The absolute risk and intensity of TS and GI using a VAS. ES was assessed using the Orofacial Esthetic Scale. BE was analyzed using repeated\u2010measures ANOVA. TS and GI were evaluated using the McNemar test (absolute risk) or paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test (intensity and ES scores;\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      BE was observed for both groups, with no statistical difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05) across all parameters. The absolute and intensity of TS were comparable between brush and conventional tip (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). ES was improved after bleaching (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The application tips showed equivalent bleaching efficacy and esthetic self\u2010perception, as well as similar tooth sensitivity and gingival irritation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>The brush applicator tip preserved bleaching efficacy while minimizing the volume of gel applied to the tooth surface, making it a more sustainable alternative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jerd.70277","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:06:08Z","timestamp":1791378368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of In\u2010Office Bleaching Using 35% Hydrogen Peroxide in an Attachable Syringe Varying the Application Tip: A Double\u2010Blind Randomized Clinical Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-202X","authenticated-orcid":false,"given":"Gabrielle Gomes","family":"Centenaro","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, School of Dentistry State University of Ponta Grossa  Ponta Grossa Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6226-3672","authenticated-orcid":false,"given":"Laryssa Mylenna Madruga","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, School of Dentistry State University of Ponta Grossa  Ponta Grossa Paran\u00e1 Brazil"},{"name":"IDIBO Research Group Rey Juan Carlos University  Alcorc\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8092-1836","authenticated-orcid":false,"given":"Leticia","family":"Condolo","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, School of Dentistry State University of Ponta Grossa  Ponta Grossa Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Kravchychyn","family":"Cappelletti","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, School of Dentistry State University of Ponta Grossa  Ponta Grossa Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9880-4856","authenticated-orcid":false,"given":"Alessandro D.","family":"Loguercio","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, School of Dentistry State University of Ponta Grossa  Ponta Grossa Paran\u00e1 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