{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T13:11:37Z","timestamp":1771593097851,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Eukaryotic Microbiology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>T and B cell\u2010deficient <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c <jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content> mice become severely ill and die of amebic encephalitis after intranasal infection with <jats:italic>Balamuthia mandrillaris<\/jats:italic>, while adult immunocompetent <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c wild\u2010type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) mice are resistant. To further investigate the role of lymphocytes in protection from <jats:italic>Balamuthia<\/jats:italic> amebic encephalitis (<jats:styled-content style=\"fixed-case\">BAE<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content> mice were reconstituted with and <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> mice selectively depleted of lymphocytes before infection. Reconstitution of <jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content> mice with whole spleen cells from <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> mice rendered the recipients as resistant to <jats:styled-content style=\"fixed-case\">BAE<\/jats:styled-content> as <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> mice. <jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content> mice that had received spleen cells depleted of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells remained susceptible. When adult <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> mice were depleted of both <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells or of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells alone, these mice also became susceptible to <jats:styled-content style=\"fixed-case\">BAE<\/jats:styled-content>. Depletion of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells alone increased susceptibility only marginally. All morbidity and mortality data were underpinned by histological analysis of the brain.<\/jats:p>","DOI":"10.1111\/jeu.12189","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T05:13:16Z","timestamp":1414991596000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Resistance to Intranasal Infection with <i>Balamuthia mandrillaris<\/i> Amebae is T\u2010Cell Dependent"],"prefix":"10.1111","volume":"62","author":[{"given":"Albrecht F.","family":"Kiderlen","sequence":"first","affiliation":[{"name":"Division for Mycotic, Parasitic and Mycobacterial Infections Robert Koch Institute Nordufer 20 13353 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Radam","sequence":"additional","affiliation":[{"name":"Division for Mycotic, Parasitic and Mycobacterial Infections Robert Koch Institute Nordufer 20 13353 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Laube","sequence":"additional","affiliation":[{"name":"Division for Mycotic, Parasitic and Mycobacterial Infections Robert Koch Institute Nordufer 20 13353 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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