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(=Nosema, Brachiola) algerae<\/jats:italic>, the best studied species of the genus, demonstrates the broadest among microsporidia range of natural and experimental hosts, but it has never been propagated in <jats:italic>Drosophila<\/jats:italic>. We present ultrastructural analysis of development of <jats:italic>A.\u00a0algerae<\/jats:italic> in visceral muscles and adipocytes of <jats:italic>Drosophila melanogaster<\/jats:italic> 2\u00a0wk after per oral experimental infection. We observed typical to <jats:italic>Anncaliia<\/jats:italic> spp. features of ultrastructure and cell pathology including spore morphology, characteristic extensions of the plasma membrane, and presence of \u201cridges\u201d and appendages of tubular material at proliferative stages. <jats:italic>Anncaliia algerae<\/jats:italic> development in <jats:italic>D.\u00a0melanogaster<\/jats:italic> was particularly similar to one of <jats:italic>A.\u00a0algerae<\/jats:italic> and <jats:italic>A.(Brachiola) vesicularum<\/jats:italic> in humans with acute myositis. Given <jats:italic>D.\u00a0melanogaster<\/jats:italic> is currently the most established genetic model, with a fully sequenced genome and easily available transgenic forms and genomic markers, a novel host\u2013parasite system might provide new genetic tools to investigate host\u2013pathogen interactions of <jats:italic>A.\u00a0algerae<\/jats:italic>, as well to test antimicrosporidia drugs.<\/jats:p>","DOI":"10.1111\/jeu.12762","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T06:59:57Z","timestamp":1568703597000},"page":"125-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Development of <i>Anncaliia algerae<\/i> (Microsporidia) in <i>Drosophila melanogaster<\/i>"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0448-7226","authenticated-orcid":false,"given":"Yuliya Y.","family":"Sokolova","sequence":"first","affiliation":[{"name":"Institute of Cytology 4 Tikhoretsky Av\\194064, St. Petersburg Russia"},{"name":"Louisiana State University Life Sciences Bldg, Baton Rouge Louisiana 70803 USA"},{"name":"The George Washington University Washington District of Columbia 20037 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl","family":"Weidner","sequence":"additional","affiliation":[{"name":"Louisiana State University Life Sciences Bldg, Baton Rouge Louisiana 70803 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"DiMario","sequence":"additional","affiliation":[{"name":"Louisiana State University Life Sciences Bldg, Baton Rouge Louisiana 70803 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2016.10.011"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz285"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2987\/8756-971X(2007)23[3:MPOM]2.0.CO;2"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1985.tb04056.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1998.tb04532.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.2004.tb00608.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.14411\/fp.2005.007"},{"key":"e_1_2_5_9_1","first-page":"405","article-title":"Ultrastructural observations on the development of Nosema algerae Vavra and Undeen (Microsporidia: Nosematidae)","volume":"9","author":"Canning E. 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