{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:22:21Z","timestamp":1764174141226,"version":"3.37.3"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T00:00:00Z","timestamp":1430784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Portuguese Science and Technology Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Fish Biology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>The micro\u2010anatomical changes associated with lordotic and kyphotic vertebral curvatures (<jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>) in juvenile and adult Senegalese sole <jats:italic>Solea senegalensis<\/jats:italic> are described. In addition, it is demonstrated that the tissue and cellular structures of individual vertebrae can be severely affected. Two main conformations were found in deformed juvenile specimens: flattened vertebrae with dorso\u2010ventral compression and trapezoidal vertebrae forming concave and convex sides under compressive and tensile stresses. Histological analyses revealed the occurrence of an ectopic cartilaginous tissue within the acellular bone, both in juveniles and adults, possibly to cope with altered mechanical stress in deformed vertebrae. The results suggest that the alteration in loading to which curved vertebral columns are subjected might trigger vertebral reshaping and differentiation of cells towards this ectopic tissue. In addition, mesenchymal cells appear to play an important role in its formation. It is here proposed that the acellular bone of <jats:italic>S. senegalensis<\/jats:italic> is capable of adaptively responding to altered loading regimes at the structural level by reshaping vertebrae and at the micro\u2010anatomical level by recruiting chondrocyte\u2010like cells to areas of altered mechanical stress.<\/jats:p>","DOI":"10.1111\/jfb.12686","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T14:42:16Z","timestamp":1430836936000},"page":"1796-1810","source":"Crossref","is-referenced-by-count":11,"title":["Micro\u2010anatomical characterization of vertebral curvatures in Senegalese sole <i>Solea senegalensis<\/i>"],"prefix":"10.1111","volume":"86","author":[{"given":"J.","family":"Cardeira","sequence":"first","affiliation":[{"name":"CCMAR \u2010 Centre of Marine Sciences University of Algarve, Campus de Gambelas  8005\u2010139 Faro Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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