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To investigate the function of GLUT4, carp <jats:italic>glut4<\/jats:italic> was first isolated. The open reading frame of carp <jats:italic>glut4<\/jats:italic> was 1518\u2009bp in length, encoding 505 amino acids. A high\u2010sequence homology was identified in carp and teleost, and the phylogenetic tree displayed that the carp GLUT4 was clustered with the teleost. A high level of <jats:italic>glut4<\/jats:italic> mRNA was analysed in fat, red muscle and white muscle. After fasting treatment, <jats:italic>glut4<\/jats:italic> mRNA expression was increased significantly in muscle. In the oral glucose tolerance test experiment, <jats:italic>glut4<\/jats:italic> mRNA was also significantly elevated in muscle, gut and fat. Furthermore, intraperitoneal injection of insulin resulted in the upregulation of <jats:italic>glut4<\/jats:italic> gene expression significantly in white muscle, gut and fat. On the contrary, the <jats:italic>glut4<\/jats:italic> mRNA level in the white muscle, gut and fat was markedly downregulated after glucagon injection. These results suggest that GLUT4 might play important roles in food intake and could be regulated by nutrient condition, insulin and glucagon in common carp. Our study is the first to report on GLUT4 in common carp. These data provide a basis for further study on fish GLUT4.<\/jats:p>","DOI":"10.1111\/jfb.14885","type":"journal-article","created":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T20:44:22Z","timestamp":1629578662000},"page":"1843-1856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Molecular identification of glucose transporter 4: The responsiveness to starvation, glucose, insulin and glucagon on glucose transporter 4 in common carp (<i>Cyprinus carpio<\/i><scp>L<\/scp>.)"],"prefix":"10.1111","volume":"99","author":[{"given":"Liping","family":"Yang","sequence":"first","affiliation":[{"name":"College of Fisheries, Engineering Technology Research Center of Henan Province for Aquatic Animal Cultivation Henan Normal University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyang","family":"Zhi","sequence":"additional","affiliation":[{"name":"College of Fisheries, 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