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This study investigated the effects of low\u2010dose <jats:italic>P. salmonis<\/jats:italic> infection (1\u2009\u00d7\u200910<jats:sup>2<\/jats:sup>\u2009CFU\/ml) on Atlantic salmon. In this study, we challenged fish with an isolated representative of the EM\u201090 genogroup <jats:italic>via<\/jats:italic> intraperitoneal injection for 42\u2009days. Infected fish displayed decreased haematocrit and haemoglobin levels at day 13 post\u2010infection, indicating erythropenia, haemolysis and haemodilution. Conversely, their white blood cell counts increased on days 13 and 21 post\u2010infection. Additionally, their iron levels decreased from day 2 post\u2010infection, indicating iron deficiency and an inability to retrieve stored iron before infection. Their magnesium levels also decreased at day 28 post\u2010infection, possibly due to osmoregulatory problems. Also, we observed an increase in lactate dehydrogenase activity on days 5, 21, and 28 post\u2010infection, suggesting early symptoms of hepatotoxicity. Later analyses determined a decrease in plasma glucose levels from day 2 post\u2010infection. This may be attributed to the hypoxic conditions caused by <jats:italic>P. salmonis<\/jats:italic>, leading to an excess utilization of stored carbohydrates. Our results suggest that the blood parameters we studied are useful for monitoring the physiological status of Atlantic salmon infected with <jats:italic>P. salmonis<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/jfb.15167","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T12:19:41Z","timestamp":1657887581000},"page":"1021-1032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of low\u2010dose <i>Piscirickettsia salmonis<\/i> infection on haematological\u2010biochemical blood parameters in Atlantic salmon (<i>Salmo salar<\/i>)"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2168-4029","authenticated-orcid":false,"given":"Adolfo","family":"Isla","sequence":"first","affiliation":[{"name":"Instituto de Bioqu\u00edmica y Microbiolog\u00eda, Facultad de Ciencias Universidad Austral de Chile  Valdivia Chile"},{"name":"Departamento de Ciencias 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