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In this study, <jats:italic>Acipenser baerii<\/jats:italic> <jats:italic>RIPK2<\/jats:italic> (<jats:italic>AbRIPK2<\/jats:italic>) was identified. The open reading frame of <jats:italic>AbRIPK2<\/jats:italic> was 1815\u2009bp encoding 604 amino acids. AbRIPK2 possessed the typical N\u2010terminal kinase domain (KD) and C\u2010terminal caspase recruitment domain (CARD). The phylogenetic tree analysis revealed that AbRIPK2 shared a relatively high identity with bony fish. Real\u2010time fluorescence quantitative PCR (qRT\u2010PCR) results indicated that <jats:italic>AbRIPK2<\/jats:italic> was highly expressed in the gill, followed by muscle, liver and heart. <jats:italic>AbRIPK2<\/jats:italic> was significantly induced in the spleen and valvular intestine after <jats:italic>Streptococcus iniae<\/jats:italic> and <jats:italic>Aeromonas hydrophila<\/jats:italic> infection. <jats:italic>AbRIPK2<\/jats:italic> was significantly upregulated after peptidoglycan (PGN) treatment in the splenic leukocytes. This study indicated that AbRIPK2 played a potential role in resisting the pathogenic infection of Siberian sturgeon by responding to bacteria.<\/jats:p>","DOI":"10.1111\/jfb.15250","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T07:44:37Z","timestamp":1665992677000},"page":"178-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification and expression profiling of receptor\u2010interacting serine\/threonine\u2010protein kinase 2 in Siberian sturgeon (<i>Acipenser baerii<\/i>)"],"prefix":"10.1111","volume":"102","author":[{"given":"Lu","family":"Lu","sequence":"first","affiliation":[{"name":"Aquaculture Department College of Animal Science &amp; Technology, Sichuan Agricultural University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaotong","family":"Dai","sequence":"additional","affiliation":[{"name":"Aquaculture Department 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