{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:51:14Z","timestamp":1789624274628,"version":"build-2803163510"},"reference-count":92,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001725","name":"Royal Swedish Academy of Sciences","doi-asserted-by":"publisher","award":["BS2019\u20100043"],"award-info":[{"award-number":["BS2019\u20100043"]}],"id":[{"id":"10.13039\/501100001725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["FR\u20102020\/0008"],"award-info":[{"award-number":["FR\u20102020\/0008"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019\u201004251"],"award-info":[{"award-number":["2019\u201004251"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Biology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Thiamin is an essential water\u2010soluble B vitamin known for its wide range of metabolic functions and antioxidant properties. Over the past decades, reproductive failures induced by thiamin deficiency have been observed in several salmonid species worldwide, but it is unclear why this micronutrient deficiency arises. Few studies have compared thiamin concentrations in systems of salmonid populations with or without documented thiamin deficiency. Moreover, it is not well known whether and how thiamin concentration changes during the marine feeding phase and the spawning migration. Therefore, samples of Atlantic salmon (\n                    <jats:italic>Salmo salar<\/jats:italic>\n                    ) were collected when actively feeding in the open Baltic Sea, after the sea migration to natal rivers, after river migration, and during the spawning period. To compare populations of Baltic salmon with systems without documented thiamin deficiency, a population of landlocked salmon located in Lake V\u00e4nern (Sweden) was sampled as well as salmon from Norwegian rivers draining into the North Atlantic Ocean. Results showed the highest mean thiamin concentrations in Lake V\u00e4nern salmon, followed by North Atlantic, and the lowest in Baltic populations. Therefore, salmon in the Baltic Sea seem to be consistently more constrained by thiamin than those in other systems. Condition factor and body length had little to no effect on thiamin concentrations in all systems, suggesting that there is no relation between the body condition of salmon and thiamin deficiency. In our large spatiotemporal comparison of salmon populations, thiamin concentrations declined toward spawning in all studied systems, suggesting that the reduction in thiamin concentration arises as a natural consequence of starvation rather than to be related to thiamin deficiency in the system. These results suggest that factors affecting accumulation during the marine feeding phase are key for understanding the thiamin deficiency in salmonids.\n                  <\/jats:p>","DOI":"10.1111\/jfb.15584","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T08:05:15Z","timestamp":1697097915000},"page":"807-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Thiamin dynamics during the adult life cycle of Atlantic salmon (\n                    <i>Salmo salar<\/i>\n                    )"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0327-9547","authenticated-orcid":false,"given":"Vittoria","family":"Todisco","sequence":"first","affiliation":[{"name":"Centre for Ecology and Evolution in Microbial Model Systems (EEMiS) Linnaeus University  Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Fridolfsson","sequence":"additional","affiliation":[{"name":"Centre for Ecology and Evolution in Microbial Model Systems (EEMiS) Linnaeus University  Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Ax\u00e9n","sequence":"additional","affiliation":[{"name":"Section for Fish National Veterinary Institute (SVA)  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Dahlgren","sequence":"additional","affiliation":[{"name":"Institution of Aquatic Resources Swedish University of Agricultural Sciences (SLU)  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej J.","family":"Ejsmond","sequence":"additional","affiliation":[{"name":"Centre for Ecology and Evolution in Microbial Model Systems (EEMiS) Linnaeus University  Kalmar Sweden"},{"name":"Institute of Environmental Science Jagiellonian University  Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc M.","family":"Hauber","sequence":"additional","affiliation":[{"name":"Centre for Ecology and Evolution in Microbial Model Systems (EEMiS) Linnaeus University  Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjetil","family":"Hindar","sequence":"additional","affiliation":[{"name":"Norwegian Institute for Nature Research (NINA)  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petter","family":"Tibblin","sequence":"additional","affiliation":[{"name":"Centre for Ecology and Evolution in Microbial Model Systems (EEMiS) Linnaeus University  Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Z\u00f6ttl","sequence":"additional","affiliation":[{"name":"Centre for Ecology and Evolution in Microbial Model Systems (EEMiS) Linnaeus University  Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"S\u00f6derberg","sequence":"additional","affiliation":[{"name":"Institution of Aquatic Resources Swedish University of Agricultural Sciences (SLU)  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Hylander","sequence":"additional","affiliation":[{"name":"Centre for Ecology and Evolution in Microbial Model Systems (EEMiS) Linnaeus University  Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"48","article-title":"Thiamine (vitamin B\u20101) concentrations in salmon (Salmo salar), brown trout (Salmo trutta) and cod (Gadus morhua) from the Baltic Sea","volume":"28","author":"Amcoff P.","year":"1999","journal-title":"Ambio"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"67","article-title":"Organohalogen substances in muscle, egg and blood from healthy Baltic salmon (Salmo salar) and Baltic salmon that produced offspring with the M74 syndrome","volume":"28","author":"Asplund L.","year":"1999","journal-title":"Ambio"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38821"},{"key":"e_1_2_9_5_1","article-title":"Fitting linear mixed\u2010effects models using lme4","author":"Bates D.","year":"2014","journal-title":"arXiv Preprint arXiv:1406.5823"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"30","article-title":"Reconditioning of sea\u2010run Baltic salmon (Salmo salar) that have produced progeny with the M74 syndrome","volume":"28","author":"B\u00f6rjeson H.","year":"1999","journal-title":"Ambio"},{"key":"e_1_2_9_7_1","first-page":"18","article-title":"Thiamine and early mortality syndrome in lake trout","volume":"21","author":"Brown S.","year":"1998","journal-title":"Thiamine and Early Mortality Syndrome in Lake Trout"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1577\/H03-072.1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1577\/H04-015.1"},{"key":"e_1_2_9_10_1","first-page":"93","article-title":"Thiamine therapy of M74 affected fry of Atlantic salmon Salmo salar","volume":"15","author":"Bylund G.","year":"1995","journal-title":"Bulletin of the European Association of Fish Pathologists (United Kingdom)"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-294X.2000.105312.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00097-06"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1577\/H07-056.1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.2012.03304.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaeng.2016.04.007"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2006.04.014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46422-2"},{"issue":"4","key":"e_1_2_9_18_1","first-page":"632","article-title":"Naturally occurring thiamine deficiency causing reproductive failure in Finger Lakes Atlantic salmon and Great Lakes lake trout (vol 125, pg 167, 1996)","volume":"125","author":"Fisher J. P.","year":"1996","journal-title":"Transactions of the American Fisheries Society"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1577\/1548-8667(1995)007<0269:PABMOT>2.3.CO;2"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0380-1330(95)71102-9"},{"issue":"1","key":"e_1_2_9_21_1","first-page":"9","article-title":"A review of early mortality syndrome (EMS) in great lakes salmonids: Relationship with thiamine deficiency","volume":"28","author":"Fitzsimons J. D.","year":"1999","journal-title":"Ambio"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/02755947.2013.806380"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1577\/h04-002.1"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00227-019-3520-6"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lno.10949"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/plankt\/fbaa015"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/plankt\/fbad004"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jglr.2019.08.005"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jglr.2017.01.001"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jglr.2019.05.010"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(01)00120-6"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2004.01091.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.1985.tb04296.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/jfbi.2001.1585"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11160-018-9538-x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.15334"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.icesjms.2006.06.004"},{"issue":"12","key":"e_1_2_9_38_1","first-page":"646","article-title":"Quantitative analysis of thiaminase activity in certain fish species","volume":"27","author":"Hirn J.","year":"1975","journal-title":"Nordisk Veterinaer Medicin"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1577\/H04-012.1"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jglr.2011.11.008"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1577\/H03-078.1"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jglr.2015.06.009"},{"key":"e_1_2_9_43_1","volume-title":"Tiaminbrist i \u00d6stersj\u00f6omr\u00e5det","author":"Hylander S.","year":"2020"},{"key":"e_1_2_9_44_1","first-page":"170","article-title":"Feeding habits of Atlantic salmon at different life stages at sea","author":"Jacobsen J.","year":"2000","journal-title":"The Ocean Life of Atlantic Salmon: Environmental and Biological Factors Influencing Survival."},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfb.14213"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-7836(02)00169-8"},{"key":"e_1_2_9_47_1","unstructured":"Kalinowski S. Manlove K. &Taper M.(2008).ONCOR: Software for genetic stock identification."},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/icesjms\/49.2.191"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fishres.2014.12.022"},{"issue":"1","key":"e_1_2_9_50_1","first-page":"37","article-title":"The diet of salmon (Salmo salar) in the Baltic Sea and connections with the M74 syndrome","volume":"28","author":"Karlsson L.","year":"1999","journal-title":"Ambio"},{"key":"e_1_2_9_51_1","first-page":"61","article-title":"The Baltic salmon (Salmo salar L.): Its history, present situation and future","volume":"10","author":"Karlsson L.","year":"1994","journal-title":"Dana"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10152-017-0484-0"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00227-018-3418-8"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/icesjms\/fss041"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1577\/1548-8659(2000)129<0607:EOTORO>2.0.CO;2"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-8286.2005.00860.x"},{"issue":"2","key":"e_1_2_9_57_1","first-page":"79","article-title":"M74 syndrome and thiamine in salmon broodfish and offspring","volume":"6","author":"Koski P.","year":"2001","journal-title":"Boreal Environment Research"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1086\/692168"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nek009"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02682257"},{"issue":"1","key":"e_1_2_9_61_1","first-page":"24","article-title":"Antioxidative systems, detoxifying enzymes and thiamine levels in Baltic salmon (Salmo salar) that develop M74","volume":"28","author":"Lundstr\u00f6m J.","year":"1999","journal-title":"Ambio"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227714"},{"key":"e_1_2_9_63_1","first-page":"92","article-title":"Mechanisms, impacts, and mitigation for thiamine deficiency and early life stage mortality in California's Central Valley Chinook Salmon","volume":"17","author":"Mantua N.","year":"2021","journal-title":"North Pacific Anadromous Fish Commission"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi401618y"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2023.739325"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2022.738877"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1139\/f95-779"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.1998.tb00964.x"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/icesjms\/fsr156"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13884-1"},{"key":"e_1_2_9_71_1","unstructured":"Nyquist N.(2022).Diet hos lax (Salmo salar) och \u00f6ring (Salmo trutta) i V\u00e4nern: Kompletterande perspektiv i en ekosystembaserad fiskf\u00f6rvaltning. In."},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-817"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1139\/f96-192"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806425115"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-8286.2004.00598.x"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2109.2005.01297.x"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-0491(98)10016-0"},{"key":"e_1_2_9_78_1","volume-title":"R Foundation for Statistical Computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-27612-5"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1139\/f2012-043"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1080\/02755947.2011.641066"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-marine-120710-100912"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.1995.tb03262.x"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2017.11.006"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-012-0156-1"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1577\/H03-081.1"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/icesjms\/fst153"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2013.08.075"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmsc.2002.1200"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10152-020-00542-9"},{"issue":"4","key":"e_1_2_9_91_1","first-page":"506","article-title":"Chelex 100 as a medium for simple extraction of DNA for PCR\u2010based typing from forensic material","volume":"10","author":"Walsh P. S.","year":"1991","journal-title":"BioTechniques"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.2007.01722.x"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.2002.tb02426.x"}],"container-title":["Journal of Fish Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jfb.15584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T02:31:10Z","timestamp":1710556270000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jfb.15584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,7]]},"references-count":92,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/jfb.15584"],"URL":"https:\/\/doi.org\/10.1111\/jfb.15584","archive":["Portico"],"relation":{},"ISSN":["0022-1112","1095-8649"],"issn-type":[{"value":"0022-1112","type":"print"},{"value":"1095-8649","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,7]]},"assertion":[{"value":"2023-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}