{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T02:37:32Z","timestamp":1776911852194,"version":"3.51.2"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Biology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Heat shock protein 70 (Hsp70) is a critical molecular chaperone in most eukaryotes and prokaryotes, significantly contributing to several physiological and biochemical processes and regulating stress response to external stimuli.\n                    <jats:italic>Gadus morhua<\/jats:italic>\n                    is a fish species with exceptionally high nutritional value and significant economic importance, making it highly meaningful to study its response strategies under pathogenic stress. However, systematic analyses of Hsp70 in\n                    <jats:italic>G. morhua<\/jats:italic>\n                    have yet to be performed. In this study, we identified 24 family members of Hsp70 genes from\n                    <jats:italic>G. morhua<\/jats:italic>\n                    and analysed their protein properties, chromosomal distribution, phylogenetic relationships, gene structure and conserved motifs. We observed that some\n                    <jats:italic>hsp70<\/jats:italic>\n                    members exhibited significantly differential expression under the stress of pathogenic bacteria and worm, suggesting that these genes could be involved in regulating pathogenic immunity. Overall, these findings provide useful information for studying cod Hsp70 gene function and evaluating its role in pathogenic immunity regulation.\n                  <\/jats:p>","DOI":"10.1111\/jfb.70459","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T01:50:12Z","timestamp":1776909012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome\u2010wide identification of the\n                    <scp>Hsp70<\/scp>\n                    gene family in\n                    <scp>Atlantic<\/scp>\n                    cod (\n                    <i>Gadus morhua<\/i>\n                    ) and its response to pathogenic stress"],"prefix":"10.1111","author":[{"given":"Miao","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Biological Science and Technology Liupanshui Normal University  Liupanshui Guizhou Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5732-4327","authenticated-orcid":false,"given":"Xinran","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology Liupanshui Normal University  Liupanshui Guizhou Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"473","article-title":"Effects of heat shock protein inducer on Hsp70 gene expression and immune parameters during streptococcus iniae infection in a Persian sturgeon fry","volume":"12","author":"Baharloei M.","year":"2021","journal-title":"Veterinary Research Forum: An International Quarterly Journal"},{"issue":"1","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"W39","DOI":"10.1093\/nar\/gkv416","article-title":"The MEME suite","volume":"43","author":"Bailey T. L.","year":"2015","journal-title":"Nucleic Acids Research"},{"issue":"6","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1093\/gbe\/evv093","article-title":"Adaptation to low salinity promotes genomic divergence in Atlantic cod (Gadus morhua L.)","volume":"7","author":"Berg P. R.","year":"2015","journal-title":"Genome Biology and Evolution"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1050323","article-title":"Atlantic cod (Gadus morhua) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals","volume":"11","author":"Bj\u00f8rnestad S. A.","year":"2023","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"25404","DOI":"10.1038\/s41598-024-76225-z","article-title":"The Atlantic cod MHC I compartment has the properties needed for cross\u2010presentation in the absence of MHC II","volume":"14","author":"Bj\u00f8rnestad S. A.","year":"2024","journal-title":"Scientific Reports"},{"issue":"15","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: A flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger A. M.","year":"2014","journal-title":"Bioinformatics"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2229-4-10","article-title":"The roles of segmental and tandem gene duplication in the evolution of large gene families in Arabidopsis thaliana","volume":"4","author":"Cannon S. B.","year":"2004","journal-title":"BMC Plant Biology"},{"issue":"1","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s43897-021-00020-x","article-title":"MG2C: A user\u2010friendly online tool for drawing genetic maps","volume":"1","author":"Chao J.","year":"2021","journal-title":"Molecular Horticulture"},{"issue":"11","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.imbio.2014.07.012","article-title":"Study on the immune response to recombinant Hsp70 protein from Megalobrama amblycephala","volume":"219","author":"Chen N.","year":"2014","journal-title":"Immunobiology"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.fsi.2016.09.009","article-title":"Hsp70 gene expansions in the scallop Patinopecten yessoensis and their expression regulation after exposure to the toxic dinoflagellate Alexandrium catenella","volume":"58","author":"Cheng J.","year":"2016","journal-title":"Fish & Shellfish Immunology"},{"issue":"4","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.fsi.2010.06.001","article-title":"Identification and molecular analysis of a stress\u2010inducible Hsp70 from Sciaenops ocellatus","volume":"29","author":"Dang W.","year":"2010","journal-title":"Fish & Shellfish Immunology"},{"issue":"12","key":"e_1_2_9_13_1","first-page":"2952","article-title":"Constitutive and inducible heat shock protein 70 immunoreactivity in the normal rat eye","volume":"40","author":"Dean D. O.","year":"1999","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"2","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/ani9020036","article-title":"The Hsp70 gene family in Boleophthalmus pectinirostris: Genome\u2010wide identification and expression analysis under high ammonia stress","volume":"9","author":"Deng Z.","year":"2019","journal-title":"Animals"},{"issue":"1","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"8907","DOI":"10.1038\/s41598-019-45193-0","article-title":"Description of strongly heat\u2010inducible heat shock protein 70 transcripts from Baikal endemic amphipods","volume":"9","author":"Drozdova P.","year":"2019","journal-title":"Scientific Reports"},{"issue":"17","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1002\/1873-3468.12751","article-title":"Hsp70\u2010a master regulator in protein degradation","volume":"591","author":"Fern\u00e1ndez\u2010Fern\u00e1ndez M. R.","year":"2017","journal-title":"FEBS Letters"},{"key":"e_1_2_9_17_1","volume-title":"The proteomics protocols handbook","author":"Gasteiger E.","year":"2005"},{"issue":"14","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147963","article-title":"Genome\u2010wide identification and interaction analysis of turbot heat shock protein 40 and 70 families suggest the mechanism of chaperone proteins involved in immune response after bacterial infection","volume":"25","author":"Geng Y.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"6","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065269","article-title":"Identification of a testis\u2010enriched heat shock protein and fourteen members of Hsp70 family in the swamp eel","volume":"8","author":"He Y.","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-11-72","article-title":"Heat\u2010shock responsive genes identified and validated in Atlantic cod (Gadus morhua) liver, head kidney and skeletal muscle using genomic techniques","volume":"11","author":"Hori T. S.","year":"2010","journal-title":"BMC Genomics"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"W585","DOI":"10.1093\/nar\/gkm259","article-title":"WoLF PSORT: Protein localization predictor","volume":"35","author":"Horton P.","year":"2007","journal-title":"Nucleic Acids Research"},{"issue":"3","key":"e_1_2_9_22_1","article-title":"Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities","volume":"3","author":"Hu C.","year":"2022","journal-title":"Medicine Communications"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1242\/jcs.03179","article-title":"A novel endothelial\u2010specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro","volume":"119","author":"Hu G.","year":"2006","journal-title":"Journal of Cell Science"},{"issue":"3","key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh A.","year":"2001","journal-title":"Journal of Molecular Biology"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"W22","DOI":"10.1093\/nar\/gkt389","article-title":"aLeaves facilitates on\u2010demand exploration of metazoan gene family trees on MAFFT sequence alignment server with enhanced interactivity","volume":"41","author":"Kuraku S.","year":"2013","journal-title":"Nucleic Acids Research"},{"issue":"9","key":"e_1_2_9_26_1","doi-asserted-by":"crossref","DOI":"10.3390\/genes11091046","article-title":"An overview of duplicated gene detection methods: Why the duplication mechanism has to be accounted for in their choice","volume":"11","author":"Lallemand T.","year":"2020","journal-title":"Genes"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3389\/fphys.2016.00511","article-title":"Different relationship between hsp70 mRNA and hsp70 levels in the heat shock response of two salmonids with dissimilar temperature preference","volume":"7","author":"Lewis M.","year":"2016","journal-title":"Frontiers in Physiology"},{"issue":"16","key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li H.","year":"2009","journal-title":"Bioinformatics"},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.825742","article-title":"A chromosome\u2010level genome assembly of yellowtail kingfish (Seriola lalandi)","volume":"12","author":"Li S.","year":"2022","journal-title":"Frontiers in Genetics"},{"key":"e_1_2_9_30_1","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.7781","article-title":"Genome\u2010wide identification and characterization of heat shock protein family 70 provides insight into its divergent functions on immune response and development of Paralichthys olivaceus","volume":"7","author":"Liu K.","year":"2019","journal-title":"PeerJ"},{"issue":"9","key":"e_1_2_9_31_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074004","article-title":"Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy","volume":"8","author":"Malmstr\u00f8m M.","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.fsi.2019.08.034","article-title":"Transcriptomic analysis of Baltic cod (Gadus morhua) liver infected with Contracaecum osculatum third stage larvae indicates parasitic effects on growth and immune response","volume":"93","author":"Marnis H.","year":"2019","journal-title":"Fish & Shellfish Immunology"},{"issue":"6","key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s00018-004-4464-6","article-title":"Hsp70 chaperones: Cellular functions and molecular mechanism","volume":"62","author":"Mayer M. P.","year":"2005","journal-title":"Cellular and Molecular Life Sciences: CMLS"},{"issue":"1","key":"e_1_2_9_34_1","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines9010034","article-title":"The use of extracellular membrane vesicles for immunization against francisellosis in Nile tilapia (Oreochromis niloticus) and Atlantic cod (Gadus morhua L.)","volume":"9","author":"Mertes V.","year":"2021","journal-title":"Vaccine"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cbd.2016.01.007","article-title":"Conserved structure and expression of hsp70 paralogs in teleost fishes","volume":"18","author":"Metzger D. C.","year":"2016","journal-title":"Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics"},{"issue":"5","key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1093\/molbev\/msaa015","article-title":"IQ\u2010TREE 2: New models and efficient methods for phylogenetic inference in the genomic era","volume":"37","author":"Minh B. Q.","year":"2020","journal-title":"Molecular Biology and Evolution"},{"issue":"1","key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0014-5793(00)01538-6","article-title":"Cloning and expression analysis of an inducible HSP70 gene from tilapia fish","volume":"474","author":"Molina A.","year":"2000","journal-title":"FEBS Letters"},{"key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s11270-018-3920-0","article-title":"HSP70 as a biomarker: An excellent tool in environmental contamination analysis\u2010a review","volume":"229","author":"Moreira\u2010de\u2010Sousa C.","year":"2018","journal-title":"Water, Air, and Soil Pollution"},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijppaw.2022.08.006","article-title":"The effects of Contracaecum osculatum larvae on the growth of Atlantic cod (Gadus morhua)","volume":"19","author":"Oveg\u00e5rd M.","year":"2022","journal-title":"International Journal for Parasitology. Parasites and Wildlife"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.338.6105.316","article-title":"Evolution. Gene duplication's role in evolution gets richer, more complex","volume":"338","author":"Pennisi E.","year":"2012","journal-title":"Science"},{"issue":"3","key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA\u2010seq reads","volume":"33","author":"Pertea M.","year":"2015","journal-title":"Nature Biotechnology"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s13762-023-04971-0","article-title":"Heat shock protein 70 reflected the state of inhabited fish response to water quality within lake ecosystem","volume":"21","author":"Rangaswamy B.","year":"2024","journal-title":"International Journal of Environmental Science and Technology"},{"issue":"7","key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/etc.4415","article-title":"Effects of mine tailings exposure on early life stages of Atlantic cod","volume":"38","author":"Reinardy H. C.","year":"2019","journal-title":"Environmental Toxicology and Chemistry"},{"issue":"11","key":"e_1_2_9_44_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41580-019-0133-3","article-title":"The Hsp70 chaperone network","volume":"20","author":"Rosenzweig R.","year":"2019","journal-title":"Nature Reviews. Molecular Cell Biology"},{"issue":"1","key":"e_1_2_9_45_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12192-011-0290-6","article-title":"Regulation of survival gene hsp70","volume":"17","author":"Silver J. T.","year":"2012","journal-title":"Cell Stress & Chaperones"},{"key":"e_1_2_9_46_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cbd.2019.04.004","article-title":"Disentangling the immune response and host\u2010pathogen interactions in Francisella noatunensis infected Atlantic cod","volume":"30","author":"Solbakken M. H.","year":"2019","journal-title":"Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics"},{"issue":"11","key":"e_1_2_9_47_1","first-page":"887","article-title":"Expression of the constitutive and inducible forms of heat shock protein 70 in human proximal tubule cells exposed to heat, sodium arsenite, and CdCl(2)","volume":"107","author":"Somji S.","year":"1999","journal-title":"Environmental Health Perspectives"},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.fsi.2015.12.009","article-title":"Genome\u2010wide identification of Hsp70 genes in channel catfish and their regulated expression after bacterial infection","volume":"49","author":"Song L.","year":"2016","journal-title":"Fish & Shellfish Immunology"},{"key":"e_1_2_9_49_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01237","article-title":"Aeromonas salmonicida subsp. salmonicida early infection and immune response of Atlantic cod (Gadus morhua L.) primary macrophages","volume":"10","author":"Soto\u2010D\u00e1vila M.","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_9_50_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature10342","article-title":"The genome sequence of Atlantic cod reveals a unique immune system","volume":"477","author":"Star B.","year":"2011","journal-title":"Nature"},{"key":"e_1_2_9_51_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.784803","article-title":"HSP90 and HSP70 families in Lateolabrax maculatus: Genome\u2010wide identification, molecular characterization, and expression profiles in response to various environmental stressors","volume":"12","author":"Sun Y.","year":"2021","journal-title":"Frontiers in Physiology"},{"key":"e_1_2_9_52_1","article-title":"Heat shock proteins and disease control in aquatic organisms","volume":"2","author":"Sung Y. Y.","year":"2013","journal-title":"Journal of Aquaculture Research & Development"},{"issue":"7","key":"e_1_2_9_53_1","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/molbev\/msab120","article-title":"MEGA11: Molecular evolutionary genetics analysis version 11","volume":"38","author":"Tamura K.","year":"2021","journal-title":"Molecular Biology and Evolution"},{"issue":"4","key":"e_1_2_9_54_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1017\/S0016672309000196","article-title":"Enhanced fixation and preservation of a newly arisen duplicate gene by masking deleterious loss\u2010of\u2010function mutations","volume":"91","author":"Tanaka K. M.","year":"2009","journal-title":"Genetics Research"},{"issue":"7","key":"e_1_2_9_55_1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/s41587-021-01156-3","article-title":"SignalP 6.0 predicts all five types of signal peptides using protein language models","volume":"40","author":"Teufel F.","year":"2022","journal-title":"Nature Biotechnology"},{"key":"e_1_2_9_56_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737777","article-title":"Characterization and expression analysis of key genes of pathogen\u2010associated molecular pattern\u2010triggered toll\u2010like receptor 5 signaling in the lined sea\u2010horse responses to bacterial and parasitic infection","volume":"549","author":"Wang X.","year":"2022","journal-title":"Aquaculture"},{"issue":"7","key":"e_1_2_9_57_1","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkr1293","article-title":"MCScanX: A toolkit for detection and evolutionary analysis of gene synteny and collinearity","volume":"40","author":"Wang Y.","year":"2012","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"e_1_2_9_58_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3354\/dao02427","article-title":"Fate of Francisella noatunensis, a pathogen of Atlantic cod Gadus morhua, in blue mussels Mytilus edulis","volume":"98","author":"Wangen I. H.","year":"2012","journal-title":"Diseases of Aquatic Organisms"},{"issue":"38","key":"e_1_2_9_59_1","doi-asserted-by":"crossref","first-page":"13526","DOI":"10.1073\/pnas.0501213102","article-title":"Evidence of functional selection pressure for alternative splicing events that accelerate evolution of protein subsequences","volume":"102","author":"Xing Y.","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"12","key":"e_1_2_9_60_1","doi-asserted-by":"crossref","DOI":"10.3390\/genes9120590","article-title":"Genome\u2010wide identification of Hsp70 genes in the large yellow croaker (Larimichthys crocea) and their regulated expression under cold and heat stress","volume":"9","author":"Xu K.","year":"2018","journal-title":"Genes"},{"issue":"9","key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/gtc.12400","article-title":"Control of the heat stress\u2010induced alternative splicing of a subset of genes by hnRNP K","volume":"21","author":"Yamamoto K.","year":"2016","journal-title":"Genes to Cells: Devoted to Molecular & Cellular Mechanisms"},{"key":"e_1_2_9_62_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103872","article-title":"Pathogenic infection and immune\u2010related gene expression of Chinese sturgeon (Acipenser sinensis) challenged by Citrobacter freundii","volume":"114","author":"Yang J.","year":"2021","journal-title":"Developmental and Comparative Immunology"},{"issue":"2","key":"e_1_2_9_63_1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.fsi.2015.07.016","article-title":"Cytokine effects and cellular signaling pathways of grass carp HSP70 in head kidney leukocytes","volume":"46","author":"Zhang A.","year":"2015","journal-title":"Fish & Shellfish Immunology"},{"issue":"1","key":"e_1_2_9_64_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10695-013-9838-y","article-title":"Characterization of four heat\u2010shock protein genes from Nile tilapia (Oreochromis niloticus) and demonstration of the inducible transcriptional activity of Hsp70 promoter","volume":"40","author":"Zhang L.","year":"2014","journal-title":"Fish Physiology and Biochemistry"},{"issue":"11","key":"e_1_2_9_65_1","doi-asserted-by":"crossref","DOI":"10.3390\/genes15111445","article-title":"Characterization of HSP70 and HSP90 gene family in Takifugu fasciatus and their expression profiles on biotic and abiotic stresses response","volume":"15","author":"Zhang W.","year":"2024","journal-title":"Genes"},{"issue":"2","key":"e_1_2_9_66_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s12192-017-0776-y","article-title":"The remarkable multivalency of the Hsp70 chaperones","volume":"22","author":"Zuiderweg E. R.","year":"2017","journal-title":"Cell Stress & Chaperones"}],"container-title":["Journal of Fish Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jfb.70459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jfb.70459","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jfb.70459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T01:50:21Z","timestamp":1776909021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jfb.70459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":65,"alternative-id":["10.1111\/jfb.70459"],"URL":"https:\/\/doi.org\/10.1111\/jfb.70459","archive":["Portico"],"relation":{},"ISSN":["0022-1112","1095-8649"],"issn-type":[{"value":"0022-1112","type":"print"},{"value":"1095-8649","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"assertion":[{"value":"2024-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jfb.70459"}}