{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:47:46Z","timestamp":1790178466981,"version":"4.1.0"},"reference-count":150,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Biochemistry"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1111\/jfbc.14390","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T10:51:17Z","timestamp":1663239077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diosgenin: An ingress towards solving puzzle for diabetes treatment"],"prefix":"10.1155","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3847-5074","authenticated-orcid":false,"given":"Prajya","family":"Arya","sequence":"first","affiliation":[{"name":"Department of Food Engineering and Technology Sant Longowal Institute of Engineering and Technology  Longowal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0690-9800","authenticated-orcid":false,"given":"Pradyuman","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Food Engineering and Technology Sant Longowal Institute of Engineering and Technology  Longowal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/ejim.ejim_109_19"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.026"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0959\u2010437x(98)80062\u20102"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960\u20109822(06)00336\u20108"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5103871"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2021.105572"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14005"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afres.2022.100054"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21\u2010S001"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)60591\u20107"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.30574\/gscbps.2021.15.3.0102"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.254.5029.274"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.05.018"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08933"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2008"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11041"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08510.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3153082"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4229"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30058-2"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.15835\/NBHA46110996"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.14.7.4902\u20104911.1994"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24122222"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3291"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X11009020"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.02.023"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010012\u20102644\u20108"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(21)00349\u20101"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/378785a0"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.22.2905"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20151"},{"key":"e_1_2_12_33_1","first-page":"2000","volume-title":"Endotext [Internet]","author":"De Meyts P","year":"2016"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3470305"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010444\u201053480\u20104.00005\u20109"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0959\u2010440x(98)80037\u20107"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.01015"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.53291"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12\u20102455"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7493694"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010019\u20102671\u20109"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.105575"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.010603"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10762"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.5.774"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.907360"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900208"},{"key":"e_1_2_12_48_1","first-page":"899","volume-title":"International textbook of diabetes mellitus","author":"Home P. D.","year":"1997"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.10.049"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2018.1539989"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.54393\/pbmj.v5i3.332"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rhisph.2021.100338"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.25004\/IJPSDR.2020.120215"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/383728a0"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7309816"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.594308"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.03.001"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.04.005"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2015.10.011"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.1493"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.16"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2008.02.006"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.12.039"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.10.2944"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2020.11.045"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.01.047"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.12.068"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.3.7306"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0889\u20108529(05)70324\u20108"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7213913"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.9.6286"},{"issue":"1","key":"e_1_2_12_72_1","first-page":"41","article-title":"Pathophysiology of type 2 diabetes and its treatment policy","volume":"53","author":"Kohei K. A. K. U.","year":"2010","journal-title":"JMAJ"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567202612666151030104810"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.8.960"},{"key":"e_1_2_12_75_1","first-page":"1","article-title":"Diabetes: Causes, symptoms and treatments","volume":"1","author":"Lal B. S.","year":"2016","journal-title":"Public Health Environment and Social Issues in India"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5385.2042"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914\u2010019\u201000538\u20106"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010020\u201002930\u20107"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2019.04.010"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114018"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.009"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20100611"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psep.2021.07.018"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110342"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.02.044"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4219"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507398"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA13188F"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v7.i17.354"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(08)60768\u20100"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1025"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfutfo.2021.09.003"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990559"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1080\/2314808X.2021.1996954"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104243"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2887"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11\u20101391"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh\u20102018\u2010001258"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.ess20137"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP\u201001\u201018\u20104479"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.03.087"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e03296"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118182"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.06.038"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041117"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20105448.2007.00274.x"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031314"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.80"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.22.6792"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.109885"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385083-6.00035-8"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2022.108131"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272\u20106386(99)70035\u20101"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000308"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2022.04.014"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v1.i3.68"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105\u2010012\u20100208\u20105"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.06.001"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2013.08.014"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2014.02.004"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.02.020"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010006\u20100475\u20101"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.13.7772"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10050645"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/810439"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3050025"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2021.11.013"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09\u20101321"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.109"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030798"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.09.022"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.4103\/jmgims.jmgims_39_19"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12\u20100073"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010014\u20102152\u2010x"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9080869"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.01.012"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.125591"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900609"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/313756a0"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-820605-8.00002-4"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.907745"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154276"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfpp.12593"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(18)69163\u2010X"},{"issue":"2","key":"e_1_2_12_147_1","first-page":"19","article-title":"Insulin and insulin resistance","volume":"26","author":"Wilcox G.","year":"2005","journal-title":"Clinical Biochemist Reviews"},{"issue":"11","key":"e_1_2_12_148_1","first-page":"3742","article-title":"Diosgenin glucoside protects against myocardial injury in diabetic mice by inhibiting RIP140 signaling","volume":"10","author":"Wu Y.","year":"2018","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9024"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010017\u20104248\u20109"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.854790"}],"container-title":["Journal of Food Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jfbc.14390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jfbc.14390","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jfbc.14390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T17:05:55Z","timestamp":1672333555000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jfbc.14390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,15]]},"references-count":150,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/jfbc.14390"],"URL":"https:\/\/doi.org\/10.1111\/jfbc.14390","archive":["Portico"],"relation":{},"ISSN":["0145-8884","1745-4514"],"issn-type":[{"value":"0145-8884","type":"print"},{"value":"1745-4514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,15]]},"assertion":[{"value":"2022-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}