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The viral disease due to white spot syndrome virus (<jats:styled-content style=\"fixed-case\">WSSV<\/jats:styled-content>) observed in early 1990s still continues unabated affecting the shrimp farms and cause huge economic loss to the shrimp aquaculture industry. In the absence of effective therapeutics to control <jats:styled-content style=\"fixed-case\">WSSV<\/jats:styled-content>, it is important to understand viral pathogenesis and shrimp response to <jats:styled-content style=\"fixed-case\">WSSV<\/jats:styled-content> at the molecular level. Identification and molecular characterization of <jats:styled-content style=\"fixed-case\">WSSV<\/jats:styled-content> proteins and receptors may facilitate in designing and development of novel therapeutics and antiviral drugs that may inhibit viral replication. Investigations into host\u2013pathogen interactions might give new insights to viral infectivity, tissue tropism and defence mechanism elicited in response to <jats:styled-content style=\"fixed-case\">WSSV<\/jats:styled-content> infection. However, due to the limited information on <jats:styled-content style=\"fixed-case\">WSSV<\/jats:styled-content> gene function and host immune response, the signalling pathways which are associated in shrimp pathogen interaction have also not been elucidated completely. In the present review, the focus is on those shrimp proteins and receptors that are potentially involved in virus infection or in the defence mechanism against <jats:styled-content style=\"fixed-case\">WSSV<\/jats:styled-content>. In addition, the major signalling pathways involved in the innate immune response and the role of apoptosis in host\u2013pathogen interaction is discussed.<\/jats:p>","DOI":"10.1111\/jfd.12279","type":"journal-article","created":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T15:56:03Z","timestamp":1403538963000},"page":"599-612","source":"Crossref","is-referenced-by-count":39,"title":["Recent insights into host\u2013pathogen interaction in white spot syndrome virus infected penaeid shrimp"],"prefix":"10.1111","volume":"38","author":[{"given":"M S","family":"Shekhar","sequence":"first","affiliation":[{"name":"Genetics and Biotechnology Unit Central Institute of Brackishwater Aquaculture Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A G","family":"Ponniah","sequence":"additional","affiliation":[{"name":"Genetics and Biotechnology Unit Central Institute of Brackishwater Aquaculture Chennai 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