{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:45:50Z","timestamp":1777419950450,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The salmon louse, <jats:italic>Lepeophtheirus salmonis<\/jats:italic> Kr\u00f8yer, is the major obstacle facing a sustainable future for farmers of salmonids in the North Atlantic Ocean. Medicinal compounds have been the most utilized tool to prevent salmon lice infestation; however, the active compounds have become less effective or considered environmentally unfriendly in the past years. Novel medicinal compounds are thus highly desired. In two experiment series, 26 medicinal compounds were screened for their efficacy against salmon lice, in a 30\u2010min exposure and 24\u2010h exposure, respectively. Pyriprole, imidacloprid, cartap and spinetoram were effective at 50\u00a0mg\u00a0L<jats:sup>\u22121<\/jats:sup> in the short\u2010time exposure. In the 24\u2010h exposure, pyriprole, propoxur, cartap, imidacloprid, fenoxycarb, pyriproxyfen, nitenpyram, spinetoram, spiromesifen and diflubenzuron induced a high level of immobilization at 5\u00a0mg\u00a0L<jats:sup>\u22121<\/jats:sup>. The <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content><jats:sub>50<\/jats:sub> values of the effective compounds were calculated in further titration studies for both exposure periods. Several physiological and biochemical pathways were discovered as possible targets for medicinal intervention against the salmon louse.<\/jats:p>","DOI":"10.1111\/jfd.12463","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T20:05:49Z","timestamp":1459627549000},"page":"1213-1223","source":"Crossref","is-referenced-by-count":26,"title":["A screening of multiple classes of pharmaceutical compounds for effect on preadult salmon lice <i>Lepeophtheirus salmonis<\/i>"],"prefix":"10.1111","volume":"39","author":[{"given":"S M","family":"Aaen","sequence":"first","affiliation":[{"name":"NMBU School of Veterinary Science Sea Lice Research Centre Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T E","family":"Horsberg","sequence":"additional","affiliation":[{"name":"NMBU School of Veterinary Science Sea Lice Research Centre Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2014.12.006"},{"key":"e_1_2_7_3_1","article-title":"A screening of medicinal compounds for their effect on egg strings and nauplii of the salmon lice Lepeophtheirus salmonins (Kr\u00f8yer)","author":"Aaen S.M.","year":"2016","journal-title":"Journal of Fish Diseases"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.25.2211"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-937"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.21273\/HORTSCI.42.2.285"},{"key":"e_1_2_7_7_1","unstructured":"California Department of Pesticide Regulation(2005). Public Report 2005\u20102."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/es034494m"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1897\/03-124"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"e140216","DOI":"10.1098\/rsos.140216","article-title":"An investigation of the false discovery rate and the misinterpretation of p\u2010values","volume":"1","author":"Colcuhoun D.","year":"2014","journal-title":"The Royal Society Open Science"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2761.2008.01011.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.994"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12089"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2664.12111"},{"key":"e_1_2_7_15_1","volume-title":"Terapianbefaling: Behandling mot lakselus i oppdrettsanlegg (2000:02)","author":"Grave K.","year":"2000"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2004.09.004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780090502"},{"key":"e_1_2_7_18_1","series-title":"The BCPC International Congress: Crop Science and Technology. Proceedings of an International Congress Held at the SECC, Glasgow, Scotland, UK, 10\u201012 November 2003","first-page":"795","author":"Guthrie F.","year":"2003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2009.08.009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073539"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(88)90119-3"},{"key":"e_1_2_7_22_1","first-page":"A614","volume-title":"The Agrochemicals Handbook","author":"Hartley D.","year":"1987"},{"key":"e_1_2_7_23_1","first-page":"3","article-title":"The salmon lice Lepeophtheirus salmonis as the cause of disease in farmed salmonids","volume":"11","author":"H\u00e5stein T.","year":"1976","journal-title":"Rivista Italiana di Piscicoltura e Ittiopatologia"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12053"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12223"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112800399158"},{"key":"e_1_2_7_27_1","first-page":"301","article-title":"Human exposure to fipronil treated with Frontline","volume":"44","author":"Jennings K.A.","year":"2002","journal-title":"Veterinary and Human Toxicology"},{"key":"e_1_2_7_28_1","first-page":"5","article-title":"Toxicity of spiromesifen to the developmental stages of Bemisia tabaci biotype B","volume":"64","author":"Kontsedalov S.","year":"2008","journal-title":"Pest Management Science"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/es0600678"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1148744"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf021149s"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0306340"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01820-4"},{"key":"e_1_2_7_34_1","series-title":"Special Scientific Report \u2013 Wildlife No. 232","first-page":"114","volume-title":"Metabolism of Pesticides\u2010Update III","author":"Menzie C.M.","year":"1980"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.10.024"},{"key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/BF03546535","article-title":"Use of malathion against ectoparasites on lactating cows","volume":"26","author":"Muan B.","year":"1985","journal-title":"Acta Veterinaria Scandinavica"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2010.12.034"},{"key":"e_1_2_7_38_1","first-page":"231","article-title":"Sealice on salmonids: their biology and control","volume":"44","author":"Pike A.W.","year":"1999","journal-title":"Advances in Parasitology"},{"key":"e_1_2_7_39_1","first-page":"611","volume-title":"Handbook of Insecticide Toxicology, Classes of Insecticide. Vol 2. Insecticides Derived from Plants and Other Organisms","author":"Ray D.E.","year":"1991"},{"key":"e_1_2_7_40_1","first-page":"1","article-title":"Current practices in the chemotherapeutic control of sea lice infestations in aquaculture: a review","volume":"26","author":"Roth M.","year":"2006","journal-title":"Journal of Fish Diseases"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0044-8486(02)00339-3"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-014-3470-y"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.07.011"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3354\/aei00142"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12061"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215025"}],"container-title":["Journal of Fish Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjfd.12463","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjfd.12463","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jfd.12463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:45:29Z","timestamp":1696178729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jfd.12463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/jfd.12463"],"URL":"https:\/\/doi.org\/10.1111\/jfd.12463","archive":["Portico"],"relation":{},"ISSN":["0140-7775","1365-2761"],"issn-type":[{"value":"0140-7775","type":"print"},{"value":"1365-2761","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4]]}}}