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Findings were compared to those observed at two non\u2010<jats:styled-content style=\"fixed-case\">AOC<\/jats:styled-content> sites, the Root and Kewaunee rivers. At each site, approximately 200 adult suckers were collected during their spawning migration. Raised skin lesions were observed at all sites and included discrete white spots, mucoid plaques on the body surface and fins and large papillomatous lesions on lips and\u00a0body. Microscopically, hyperplasia, papilloma and squamous cell carcinoma were documented. Liver neoplasms were also observed at all sites and included both hepatocellular and biliary tumours. Based on land use, the Kewaunee River was the site least impacted by human activities previously associated with fish tumours and had significantly fewer liver neoplasms when compared to the other sites. The proportion of white suckers with liver tumours followed the same patterns as the proportion of urban land use in the watershed: the Milwaukee Estuary had the highest prevalence, followed by the Root, Sheboygan and Kewaunee rivers. The overall skin neoplasm (papilloma and carcinoma) prevalence did not follow the same pattern, although the percentage of white suckers with squamous cell carcinoma exhibited a similar relationship to land use. Testicular tumours (seminoma) were observed at both <jats:styled-content style=\"fixed-case\">AOC<\/jats:styled-content> sites but not at the non\u2010<jats:styled-content style=\"fixed-case\">AOC<\/jats:styled-content> sites. Both skin and liver tumours were significantly and positively associated with age but not sex.<\/jats:p>","DOI":"10.1111\/jfd.12520","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T10:16:41Z","timestamp":1472033801000},"page":"377-393","source":"Crossref","is-referenced-by-count":26,"title":["Tumours in white suckers from Lake Michigan tributaries: pathology and prevalence"],"prefix":"10.1111","volume":"40","author":[{"given":"V S","family":"Blazer","sequence":"first","affiliation":[{"name":"Fish Health Branch Leetown Science Center U.S. Geological Survey Kearneysville WV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H L","family":"Walsh","sequence":"additional","affiliation":[{"name":"Division of Forestry and Natural Resources West Virginia University Morgantown WV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R P","family":"Braham","sequence":"additional","affiliation":[{"name":"Fish Health Branch Leetown Science Center U.S. Geological Survey Kearneysville WV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Hahn","sequence":"additional","affiliation":[{"name":"Fish Health Branch Leetown Science Center U.S. Geological Survey Kearneysville WV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Mazik","sequence":"additional","affiliation":[{"name":"West Virginia Cooperative Fish and Wildlife Unit U.S. Geological Survey West Virginia University Morgantown WV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P B","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Center for Limnology University of Wisconsin\u2010Madison Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602538409041078"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","unstructured":"BaldwinA.K. 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