{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:23:47Z","timestamp":1784370227270,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T00:00:00Z","timestamp":1495756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007465","name":"Universitetet i Troms\u00f8","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007465","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Atlantic lumpfish (<jats:italic>Cyclopterus lumpus<\/jats:italic> L.) is used as a biological delousing agent for sea lice (<jats:italic>Lepeophtheirus salmonis<\/jats:italic> K.) infestations in Norwegian aquaculture. Here, we present a study on the antibody response and vaccine side effects after intramuscular and intraperitoneal injection of lumpfish with two vaccines. Both vaccines contained bacterial antigens from atypical <jats:italic>Aeromonas salmonicida<\/jats:italic> A\u2010layer types V and <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>,<jats:italic> Vibrio anguillarum<\/jats:italic> serotype O1 and <jats:italic>Moritella viscosa<\/jats:italic> sp., but one vaccine contained a vegetable oil\u2010based adjuvant, while the other contained a mineral oil\u2010based adjuvant. Intramuscular injection of the mineral oil\u2010based vaccine caused a high acute mortality of fish within 48\u00a0hr after immunization. Intraperitoneal injection of the mineral oil\u2010based vaccine resulted in a lower severity of intra\u2010abdominal side effects than the vegetable oil\u2010based vaccine. Intramuscular injection of the mineral oil\u2010based vaccine resulted in a significantly higher antibody response against <jats:italic>A.\u00a0salmonicida<\/jats:italic> when compared to controls and the vegetable oil\u2010based vaccine group. The antibody response was poor against <jats:italic>V.\u00a0anguillarum<\/jats:italic> and <jats:italic>M.\u00a0viscosa<\/jats:italic> for all groups. Our results indicate that intramuscular injection of oil\u2010based vaccines might be feasible for providing immunological protection for Atlantic lumpfish against bacterial diseases, especially atypical <jats:italic>A.\u00a0salmonicida<\/jats:italic>, but more work is required to identity optimal adjuvants.<\/jats:p>","DOI":"10.1111\/jfd.12649","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T13:12:46Z","timestamp":1495804366000},"page":"1805-1813","source":"Crossref","is-referenced-by-count":31,"title":["Studies on the antibody response and side effects after intramuscular and intraperitoneal injection of Atlantic lumpfish (<i>Cyclopterus lumpus<\/i> L.) with different oil\u2010based vaccines"],"prefix":"10.1111","volume":"40","author":[{"given":"T","family":"Erkinharju","sequence":"first","affiliation":[{"name":"Norwegian College of Fishery Science University of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M R","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Norwegian College of Fishery Science University of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Isdal","sequence":"additional","affiliation":[{"name":"Vaxxinova Norway AS Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Hordvik","sequence":"additional","affiliation":[{"name":"Department of Biology University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Dalmo","sequence":"additional","affiliation":[{"name":"Norwegian College of Fishery Science University of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5010-5095","authenticated-orcid":false,"given":"T","family":"Seternes","sequence":"additional","affiliation":[{"name":"Norwegian College of Fishery Science University of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00498-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2761.2007.00899.x"},{"key":"e_1_2_6_4_1","volume-title":"Dyrevelferdsmessige konsekvenser av vaksinasjon av fisk \u2010 effekter og bivirkninger","author":"Berg A.","year":"2006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3354\/dao069239"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12450"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2016.09.063"},{"key":"e_1_2_6_8_1","volume-title":"Akutt d\u00f8delighet hos rognkjeks (Cyclopterus lumpus) i 2015","author":"Born\u00f8 G.","year":"2016"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/fsim.2002.0439"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118806913.ch15"},{"key":"e_1_2_6_11_1","volume-title":"Synopsis of biological data on the lumpsucker Cyclopterus lumpus (Linnaeus, 1758)","author":"Davenport J.","year":"1985"},{"key":"e_1_2_6_12_1","unstructured":"Fl\u00f8gum V. A.(2016).Vaksinering av berggylt (Labrus bergylta) mot Aeromonas salmonicida A\u2010lagstype V og VI. MSc Masters thesis University of Bergen."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.10.105"},{"key":"e_1_2_6_14_1","unstructured":"Ghebretnsae D. B.(2015).Adaptive humoral immune response in lumpfish Cyclopterus lumpus L. 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Lund V. &Gudmundsdottir B.(2008).Side effects of injectable vaccines in cod \u2010 Adapting the side\u2010effect scale to cod[Online]. 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