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In the present study, the farmed striped catfish <jats:italic>Pangasianodon hypophthalmus<\/jats:italic> (14\u201315\u00a0cm, 70\u201390\u00a0g) with a history of cumulative mortality of about 23% during June and July 2015, were brought to the laboratory. The histopathological examination of gills from the affected fish revealed presence of granular basophilic intracellular inclusions, mostly at the base of the interlamellar region and in gill filaments. A concurrent infection with <jats:italic>Trichodina<\/jats:italic> spp., <jats:italic>Ichthyobodo<\/jats:italic> spp. and <jats:italic>Dactylogyrus<\/jats:italic> spp. was observed in the gills. The presence of chlamydial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> in the gills of affected fish was confirmed by amplification and sequencing of 16S <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content> gene. <jats:styled-content style=\"fixed-case\">BLAST<\/jats:styled-content>\u2010n analysis of these amplicons revealed maximum similarity (96%) with <jats:italic>Candidatus<\/jats:italic> Actinochlamydia clariae. On the basis of phylogenetic analysis, it was inferred that the epitheliocystis agents from striped catfish were novel and belonged to the taxon <jats:italic>Ca<\/jats:italic>. Actinochlamydia. It is proposed that epitheliocystis agents from striped catfish will be named as <jats:italic>Ca<\/jats:italic>. Actinochlamydia pangasiae. The 16S <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content> gene amplicons from novel chlamydiae were labelled and linked to inclusions by in\u00a0situ hybridisation. This is the first report of epitheliocystis from India in a new fish host <jats:italic>P. hypophthalmus<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/jfd.12711","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T11:38:39Z","timestamp":1506080319000},"page":"281-290","source":"Crossref","is-referenced-by-count":22,"title":["<i>Candidatus<\/i> Actinochlamydia pangasiae sp. nov. 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