{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T09:48:19Z","timestamp":1789897699146,"version":"4.0.1"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["237315\/E40"],"award-info":[{"award-number":["237315\/E40"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["239140"],"award-info":[{"award-number":["239140"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007465","name":"Universitetet i Troms\u00f8","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007465","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recently in 2016, the European Medicines Agency (\n                    <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content>\n                    ) recommended granting a marketing authorization in the\n                    <jats:styled-content style=\"fixed-case\">EU<\/jats:styled-content>\n                    for \u201cClynav,\u201d a\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    vaccine against salmon pancreas disease (salmonid alphavirus\u20103). Generally,\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    vaccines induce both early and late immune responses in fish that may be protective against disease. Several transcriptomic approaches have been performed to map immunome profiles following\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    vaccination, but the precise immune mechanism(s) that is responsible for protection is not known, although reasonable suggestions have been made. The current review includes an overview on main transcriptomic findings from microarray experiments after\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    vaccination against\n                    <jats:styled-content style=\"fixed-case\">VHSV<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">IHNV<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">HIRRV<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">IPNV<\/jats:styled-content>\n                    \u2014with considerations of what can be considered as correlates of protection (CoP) or merely a surrogate of protection. Identification and use of correlates of protection (\n                    <jats:styled-content style=\"fixed-case\">COP<\/jats:styled-content>\n                    s) may be a strategic tool for accelerated and targeted vaccine design, testing and licensure. General rules on what can be considered as CoPs can be extracted from past knowledge on protective immune responses following vaccination that induced protection. Lastly, there will be an overview on non\u2010viral molecular adjuvants that have been exploited to obtain higher vaccine potencies and efficacies.\n                  <\/jats:p>","DOI":"10.1111\/jfd.12727","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T06:16:40Z","timestamp":1508825800000},"page":"1-9","source":"Crossref","is-referenced-by-count":84,"title":["<scp>DNA<\/scp>\n                    vaccines for fish: Review and perspectives on correlates of protection"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-9859","authenticated-orcid":false,"given":"R A","family":"Dalmo","sequence":"first","affiliation":[{"name":"Faculty of Biosciences Fisheries &amp; Economics Norwegian College of Fishery Science University of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/fsim.2001.0373"},{"key":"e_1_2_8_3_1","first-page":"114","article-title":"Genetic immunization of rainbow trout (Oncorhynchus mykiss) against infectious hematopoietic necrosis virus","volume":"5","author":"Anderson E. 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