{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:53:00Z","timestamp":1791474780092,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CENAKVA","award":["CZ.1.05\/2.1.00\/01.0024"],"award-info":[{"award-number":["CZ.1.05\/2.1.00\/01.0024"]}]},{"name":"CENAKVA II","award":["LO1205"],"award-info":[{"award-number":["LO1205"]}]},{"name":"GAJU","award":["012\/2016\/Z"],"award-info":[{"award-number":["012\/2016\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study evaluated efficacy and toxicity of the pyrazinoisoquinoline anthelmintic praziquantel (<jats:styled-content style=\"fixed-case\">PZQ<\/jats:styled-content>) in barbel infected with metacercariae of <jats:italic>Diplostomum spathaceum<\/jats:italic> and adult <jats:italic>Pomphorhynchus laevis,<\/jats:italic> and assessed antioxidant biomarkers and the lipid peroxidation response in juvenile barbel post\u2010treatment. The estimated 96\u2010hr <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>50 of <jats:styled-content style=\"fixed-case\">PZQ<\/jats:styled-content> was 28.6\u00a0mg\/L. For evaluation of efficacy, barbel naturally infected with <jats:italic>D.\u00a0spathaceum<\/jats:italic> were exposed to a 10 and 20\u00a0mg\/L <jats:styled-content style=\"fixed-case\">PZQ<\/jats:styled-content> 4\u2010day bath treatment. Both concentrations were 100% effective against <jats:italic>D.\u00a0spathaceum<\/jats:italic> and significantly (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.01) affected the activity of catalase, superoxide dismutase, glutathione reductase and glutathione\u2010S\u2010transferase as well as levels of reduced glutathione in liver and muscle. The efficacy of orally administered <jats:styled-content style=\"fixed-case\">PZQ<\/jats:styled-content> was assessed in adult barbel naturally infected with <jats:italic>P.\u00a0laevis<\/jats:italic>. Fish were administered 10, 30 and 50\u00a0mg\/kg of body weight and examined via gut dissection after 6\u00a0days. The 50\u00a0mg\/kg dose significantly decreased the intensity of infection. Praziquantel is a feasible bath treatment for barbel infected with <jats:italic>D.\u00a0spathaceum<\/jats:italic> and has potential for oral treatment of broodfish infected with <jats:italic>P.\u00a0laevis<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/jfd.12764","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T05:36:38Z","timestamp":1516340198000},"page":"643-649","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy and toxicity of praziquantel in helminth\u2010infected barbel (<i>Barbus barbus<\/i> L.)"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2465-1409","authenticated-orcid":false,"given":"E","family":"Zuskova","sequence":"first","affiliation":[{"name":"Faculty of Fisheries and Protection of Waters South Bohemian Research Centre of Aquaculture and Biodiversity of Hydrocenoses Research Institute of Fish Culture and Hydrobiology University of South Bohemia in Ceske Budejovice Vodnany Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Piackova","sequence":"additional","affiliation":[{"name":"Faculty of Fisheries and Protection of Waters South Bohemian Research Centre of Aquaculture and Biodiversity of Hydrocenoses Research Institute of Fish Culture and Hydrobiology University of South Bohemia in Ceske Budejovice Vodnany Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Machova","sequence":"additional","affiliation":[{"name":"Faculty of Fisheries and Protection of Waters South Bohemian Research Centre of Aquaculture and Biodiversity of Hydrocenoses Research Institute of Fish Culture and Hydrobiology University of South Bohemia in Ceske Budejovice Vodnany Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Chupani","sequence":"additional","affiliation":[{"name":"Faculty of Fisheries and Protection of Waters South Bohemian Research Centre of Aquaculture and Biodiversity of Hydrocenoses Research Institute of Fish Culture and Hydrobiology University of South Bohemia in Ceske Budejovice Vodnany Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Steinbach","sequence":"additional","affiliation":[{"name":"Faculty of Fisheries and Protection of Waters South Bohemian Research Centre of Aquaculture and Biodiversity of Hydrocenoses Research Institute of Fish Culture and Hydrobiology University of South Bohemia in Ceske Budejovice Vodnany Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Stara","sequence":"additional","affiliation":[{"name":"Faculty of Fisheries and Protection of Waters South Bohemian Research Centre of Aquaculture and Biodiversity of Hydrocenoses Research Institute of Fish Culture and Hydrobiology University of South Bohemia in Ceske Budejovice Vodnany Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Velisek","sequence":"additional","affiliation":[{"name":"Faculty of Fisheries and Protection of Waters South Bohemian Research Centre of Aquaculture and Biodiversity of Hydrocenoses Research Institute of Fish Culture and Hydrobiology University of South Bohemia in Ceske Budejovice Vodnany Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005217622959"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50881-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1016\/S0021-9258(19)41206-4","article-title":"Purification and characterization of flavoenzyme glutathione reductase from rat liver","volume":"250","author":"Carlberg I.","year":"1975","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-4648(03)00007-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2761.2002.00332.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1995.0014"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2013.08.034"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12089"},{"key":"e_1_2_6_12_1","first-page":"7130","article-title":"Glutathione S\u2010transferases \u2010 first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig W. 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