{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:28:35Z","timestamp":1767918515988,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extracellular adenosine triphosphate (<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>) and its metabolite adenosine (Ado) are recognized as key mediators of immune and inflammatory responses. Depending on its concentration, <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> may act as an immunostimulant or immunodepressant, while Ado levels display an anti\u2010inflammatory profile. The aim of this study was to evaluate whether splenic purinergic signalling is capable of modulating immune and inflammatory responses in fish experimentally infected with <jats:italic>Aeromonas caviae<\/jats:italic>. Triphosphate diphosphohydrolase (<jats:styled-content style=\"fixed-case\">NTPD<\/jats:styled-content>ase) and 5\u2032\u2010nucleotidase activities increased in the spleen of silver catfish (<jats:italic>Rhamdia quelen<\/jats:italic>) experimentally infected with <jats:italic>A.\u00a0caviae<\/jats:italic> compared with the uninfected control group. Moreover, splenic Ado levels increased in the infected animals relative to the uninfected control group. Based on these lines of evidence, our findings revealed that adenine nucleotide hydrolysis is modified in the spleen of fish infected with <jats:italic>A.\u00a0caviae<\/jats:italic> attempting to restrict the inflammatory process through the upregulation of <jats:styled-content style=\"fixed-case\">NTPD<\/jats:styled-content>ase and 5\u2032\u2010nucleotidase activities, which occurs in an attempt to hydrolyse the excessive <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> in the extracellular environment and rapidly hydrolyse <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content> to form Ado. In summary, purinergic signalling can modulate immune and inflammatory responses during <jats:italic>A.\u00a0caviae<\/jats:italic> infection.<\/jats:p>","DOI":"10.1111\/jfd.12773","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T08:36:46Z","timestamp":1513672606000},"page":"683-687","source":"Crossref","is-referenced-by-count":14,"title":["Purinergic signalling displays an anti\u2010inflammatory profile in the spleen of fish experimentally infected with <i>Aeromonas caviae<\/i>: Modulation of the immune response"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-8528","authenticated-orcid":false,"given":"M D","family":"Baldissera","sequence":"first","affiliation":[{"name":"Department of Microbiology and Parasitology Universidade Federal de Santa Maria Santa Maria Rio Grande do Sul 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