{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:20:00Z","timestamp":1780096800185,"version":"3.54.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303013\/2015\u20100"],"award-info":[{"award-number":["303013\/2015\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003046","name":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Monogeneans are ectoparasites that may cause losses in production and productivity in the aquaculture of <jats:italic>Colossoma macropomum<\/jats:italic>. Chemotherapeutics used in aquaculture usually have major adverse effects on fish; hence, the use of essential oils has been considered advantageous, but these are not soluble in water. Thus, the use of nanostructures to enhance water solubility of compounds and improve bioactivity may be very promising. This study investigated the antiparasitic activity of nanoemulsion prepared with <jats:italic>Copaifera officinalis<\/jats:italic> oleoresin (50, 100, 150, 200 and 300\u00a0mg\/L), against monogenean parasites from the gills of <jats:italic>C.\u00a0macropomum<\/jats:italic>. The particle size distribution and zeta potential suggested that a potentially kinetic stable system was generated. The nanoemulsion from <jats:italic>C.\u00a0officinalis<\/jats:italic> oleoresin achieved high efficacy (100%) at low concentrations (200 and 300\u00a0mg\/L) after 15\u00a0min of exposure. This was the first time that a nanoemulsion was generated from <jats:italic>C.\u00a0officinalis<\/jats:italic> oleoresin using a solvent\u2010free, non\u2010heating and low\u2010energy method. Moreover, this was the first time that an antiparasitic against monogeneans on fish gills, based on nanoemulsion of <jats:italic>C.\u00a0officinalis<\/jats:italic> oleoresin, was tested.<\/jats:p>","DOI":"10.1111\/jfd.12793","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T06:36:03Z","timestamp":1526538963000},"page":"1041-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of a nanoemulsion with <i>Copaifera officinalis<\/i> oleoresin against monogenean parasites of <i>Colossoma macropomum:<\/i> A Neotropical Serrasalmidae"],"prefix":"10.1111","volume":"41","author":[{"given":"D S S","family":"Valentim","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Biodiversidade Tropical (PPGBIO) Universidade Federal do Amap\u00e1 Macap\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Duarte","sequence":"additional","affiliation":[{"name":"Laboratorio Nanobiotecnologia Farmac\u00eautica Universidade Federal do Amap\u00e1 Macap\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A E M F M","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratorio Nanobiotecnologia Farmac\u00eautica Universidade Federal do Amap\u00e1 Macap\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A S","family":"Cruz","sequence":"additional","affiliation":[{"name":"Laboratorio Nanobiotecnologia Farmac\u00eautica Universidade Federal do Amap\u00e1 Macap\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C T","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Biodiversidade Tropical (PPGBIO) Universidade Federal do Amap\u00e1 Macap\u00e1 Brazil"},{"name":"Laborat\u00f3rio de Pesquisas de Drogas Universidade Federal do Amap\u00e1 Macap\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Solans","sequence":"additional","affiliation":[{"name":"Instituto Avan\u00e7ado de Qu\u00edmica da Catatonia (IQAC\u2010CSIC) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C P","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Biodiversidade Tropical (PPGBIO) Universidade Federal do Amap\u00e1 Macap\u00e1 Brazil"},{"name":"Laboratorio Nanobiotecnologia Farmac\u00eautica Universidade Federal do Amap\u00e1 Macap\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8376-1846","authenticated-orcid":false,"given":"M","family":"Tavares\u2010Dias","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Biodiversidade Tropical (PPGBIO) Universidade Federal do Amap\u00e1 Macap\u00e1 Brazil"},{"name":"Embrapa Amap\u00e1 Macap\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Os frutos do tambaqui: Ecologia, conserva\u00e7\u00e3o e cultivo na Amaz\u00f4nia","author":"Ara\u00fajo\u2010Lima C.","year":"1998"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1984-82502016000300001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/1809-43921999291121"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2015.01.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)00284-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2008.04.018"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2016.11.041"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2014.05.007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2012.01.055"},{"key":"e_1_2_7_11_1","volume-title":"M\u00e9todos de estudo e t\u00e9cnicas laboratoriais em parasitologia de peixes","author":"Eiras J. 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